Influenza viruses and the NF-kappaB signaling pathway - towards a novel concept of antiviral therapy

Biological Chemistry
Stephan Ludwig, Oliver Planz

Abstract

Influenza A virus remains a major public health concern, both in its annual toll in death and debilitation and its potential to cause devastating pandemics. Like any other virus, influenza A viruses are strongly dependent on cellular factors for replication. One of the hallmark signaling factors activated by viral pathogens is the transcription factor NF-kappaB. Activation of NF-kappaB leads to the up-regulation of a variety of antiviral genes. Thus, the factor is commonly regarded as a major regulator of the innate immune defense to infection. However, several recent studies indicate that influenza viruses have acquired the capability to reprogram this antiviral activity and to exploit the factor for efficient replication. These data provide novel insights into the pathophysiological function of NF-kappaB in the special environment of a virus-infected cell. Furthermore, the unexpected viral dependency on a cellular signaling factor may pave the path for novel antiviral approaches targeting essential cellular components rather than viral factors.

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Citations

May 22, 2013·Veterinary Immunology and Immunopathology·Tufária MussáMaría Montoya
May 8, 2009·The Journal of Antimicrobial Chemotherapy·Stephan Ludwig
Oct 17, 2008·Biological Chemistry·Stephan Ludwig
Aug 21, 2008·Biological Chemistry·Stephan Pleschka
Aug 21, 2008·Biological Chemistry·Thorsten WolffMarkus Matthaei
Jul 23, 2011·Antiviral Research·Emanuel HaasbachOliver Planz
Jun 11, 2014·Journal of Medical Microbiology·Eric M VelaJames P Long
Nov 5, 2010·The Journal of General Virology·Takuya ShiozakiTadaaki Miyazaki
Jun 9, 2015·Frontiers in Microbiology·Jun-Da ZhuHwa-Chain R Wang
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Oct 26, 2020·Cellular Microbiology·Gayan BamunuarachchiLin Liu
Jan 26, 2021·Frontiers in Immunology·Praveen M VargheseUday Kishore
Jan 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Esmé Jansen van VurenBrian H Harvey

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