Informatic search strategies to discover analogues and variants of natural product archetypes

Journal of Industrial Microbiology & Biotechnology
Chad JohnstonNathan A Magarvey

Abstract

Natural products are a crucial source of antimicrobial agents, but reliance on low-resolution bioactivity-guided approaches has led to diminishing interest in discovery programmes. Here, we demonstrate that two in-house automated informatic platforms can be used to target classes of biologically active natural products, specifically, peptaibols. We demonstrate that mass spectrometry-based informatic approaches can be used to detect natural products with high sensitivity, identifying desired agents present in complex microbial extracts. Using our specialised software packages, we could elaborate specific branches of chemical space, uncovering new variants of trichopolyn and demonstrating a way forward in mining natural products as a valuable source of potential pharmaceutical agents.

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Citations

Jan 8, 2016·Journal of Industrial Microbiology & Biotechnology·Leonard Katz, Richard H Baltz
Aug 16, 2016·Journal of Industrial Microbiology & Biotechnology·Richard H Baltz
Dec 12, 2019·Natural Product Reports·Marc G ChevretteFrancisco Barona-Gómez
Oct 24, 2019·World Journal of Microbiology & Biotechnology·Rajeshwari SinhaPratyoosh Shukla
Sep 23, 2020·Pharmacology & Therapeutics·Li ZhangGuanhua Du

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