PMID: 16613562Apr 15, 2006Paper

Information management for the study of allergies

Inflammation & Allergy Drug Targets
Vladimir Brusic

Abstract

Microarrays and other large-scale screening technologies produce quantities of increasingly complex allergy data. These data link molecular and clinical measurements and observations and provide fertile ground for improving our understanding of the processes involved in allergic reactions. Information technology is employed in gathering, storage, retrieval and analysis of these data. The increasing proportion of allergy data are generated from genomics and proteomics approaches. The major activity focuses on characterization of allergens including IgE reactivity, structural properties, and mapping of IgE and T-cell epitopes. Because of the complexity of allergy data, their utilization requires bioinformatics approaches. Allergen data are stored in the general and specialist databases. At least a dozen of important allergen databases and data repositories have been developed to date. These data are analysed using general and specialist bioinformatics tools. The major applications of bioinformatics include support for allergen characterization, assessment of allergenicity, and identification of allergic cross-reactivity. These applications in turn support the development of vaccines and therapies for allergic disease. In this art...Continue Reading

Citations

Dec 21, 2006·Autoimmunity·Nikolai Petrovsky, Vladimir Brusic
Sep 11, 2007·The Journal of Allergy and Clinical Immunology·Daniel Soeria-AtmadjaUlf Hammerling

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