PMID: 16617614Apr 19, 2006Paper

Information mining over heterogeneous and high-dimensional time-series data in clinical trials databases

IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society
Fatih AltiparmakDonald C Trost

Abstract

An effective analysis of clinical trials data involves analyzing different types of data such as heterogeneous and high dimensional time series data. The current time series analysis methods generally assume that the series at hand have sufficient length to apply statistical techniques to them. Other ideal case assumptions are that data are collected in equal length intervals, and while comparing time series, the lengths are usually expected to be equal to each other. However, these assumptions are not valid for many real data sets, especially for the clinical trials data sets. An addition, the data sources are different from each other, the data are heterogeneous, and the sensitivity of the experiments varies by the source. Approaches for mining time series data need to be revisited, keeping the wide range of requirements in mind. In this paper, we propose a novel approach for information mining that involves two major steps: applying a data mining algorithm over homogeneous subsets of data, and identifying common or distinct patterns over the information gathered in the first step. Our approach is implemented specifically for heterogeneous and high dimensional time series clinical trials data. Using this framework, we propose...Continue Reading

References

Oct 5, 2001·Medical Informatics and the Internet in Medicine·S DoddiD C Torney
Jul 16, 2002·Nature Medicine·David G BeerSamir Hanash
Oct 9, 2002·Mini Reviews in Medicinal Chemistry·M G Walker

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Citations

Sep 8, 2012·Journal of the American Medical Informatics Association : JAMIA·George Hripcsak, David J Albers
Jan 16, 2008·Clinics in Laboratory Medicine·Andrew R Post, James H Harrison
Apr 17, 2015·IEEE Transactions on Bio-medical Engineering·Javier Andreu PerezGuang-Zhong Yang
Feb 7, 2009·Diabetes Care·Seward B RutkoveRachel A Nardin
Nov 6, 2007·Physiological Measurement·Seward B RutkoveRachel A Nardin
Dec 29, 2020·Journal of Biomedical Informatics·Luca BonomiXiaoqian Jiang

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