Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors

Gastroenterology
Andrew T KunzmannHelen G Coleman

Abstract

We previously developed a tool that identified individuals who later developed esophageal adenocarcinoma (based on age, sex, body mass index, smoking status, and prior esophageal conditions) with an area under the curve of 0.80. In this study, we collected data from 329,463 individuals in the UK Biobank cohort who were tested for genetic susceptibility to esophageal adenocarcinoma (a polygenic risk score based on 18 recognized genetic variants). We found that after inclusion of this genetic information, the area under the curve for identification of individuals who developed esophageal adenocarcinoma remained at 0.80. Testing for genetic variants associated with esophageal adenocarcinoma therefore seems unlikely to improve identification of individuals at risk of esophageal adenocarcinoma.

Citations

Apr 6, 2019·Alimentary Pharmacology & Therapeutics·Andrew T KunzmannHelen G Coleman
Mar 15, 2019·Current Gastroenterology Reports·Vani J A Konda, Rhonda F Souza
Aug 29, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Shao-Hua XieJesper Lagergren
Feb 20, 2021·Nature Reviews. Gastroenterology & Hepatology·Aaron P Thrift
Nov 21, 2020·Gastrointestinal Endoscopy Clinics of North America·Michael B Cook, Aaron P Thrift

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