Information processing by simple molecular motifs and susceptibility to noise

Journal of the Royal Society, Interface
Siobhan S Mc MahonMichael P H Stumpf

Abstract

Biological organisms rely on their ability to sense and respond appropriately to their environment. The molecular mechanisms that facilitate these essential processes are however subject to a range of random effects and stochastic processes, which jointly affect the reliability of information transmission between receptors and, for example, the physiological downstream response. Information is mathematically defined in terms of the entropy; and the extent of information flowing across an information channel or signalling system is typically measured by the 'mutual information', or the reduction in the uncertainty about the output once the input signal is known. Here, we quantify how extrinsic and intrinsic noise affects the transmission of simple signals along simple motifs of molecular interaction networks. Even for very simple systems, the effects of the different sources of variability alone and in combination can give rise to bewildering complexity. In particular, extrinsic variability is apt to generate 'apparent' information that can, in extreme cases, mask the actual information that for a single system would flow between the different molecular components making up cellular signalling pathways. We show how this artifici...Continue Reading

References

Aug 17, 2002·Science·Michael B ElowitzPeter S Swain
Sep 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Peter S SwainEric D Siggia
Mar 22, 2003·Current Opinion in Cell Biology·John J TysonBela Novak
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·S Mangan, U Alon
Aug 11, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·C J CellucciP E Rapp
Aug 27, 2005·IEEE Transactions on Pattern Analysis and Machine Intelligence·Hanchuan PengChris Ding
May 9, 2006·BMC Genomics·Piers J IngramJaroslav Stark
May 19, 2007·Nature Reviews. Genetics·Uri Alon
Aug 7, 2007·PLoS Computational Biology·Burton W Andrews, Pablo A Iglesias
Oct 25, 2007·PloS One·Etay ZivChris H Wiggins
Jul 23, 2008·Current Opinion in Biotechnology·Wp Kelly, Mph Stumpf
Aug 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gasper TkacikWilliam Bialek
Sep 4, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Gasper TkacikWilliam Bialek
Sep 4, 2008·Science Signaling·Martin Lee MillerRune Linding
Oct 11, 2008·PLoS Computational Biology·Piers J IngramJaroslav Stark
Jun 13, 2009·Physical Review Letters·Filipe Tostevin, Pieter Rein ten Wolde
Oct 21, 2009·BMC Bioinformatics·Michał KomorowskiDavid A Rand
Nov 13, 2009·Physical Review Letters·Robert G Endres, Ned S Wingreen
Mar 5, 2010·BMC Systems Biology·Núria Domedel-PuigLorenz Wernisch
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·David FangeJohan Elf
Apr 5, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Gašper Tkačik, Aleksandra M Walczak
May 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Michał KomorowskiMichael P H Stumpf
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·John C Doyle, Marie Csete
Sep 17, 2011·Science·Raymond CheongAndre Levchenko
Mar 2, 2012·Bioinformatics·Michal KomorowskiMichael P H Stumpf
Apr 3, 2012·Physical Review Letters·Filipe TostevinPieter Rein ten Wolde
Apr 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Clive G Bowsher, Peter S Swain
Jun 12, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Gašper TkačikWilliam Bialek
Aug 9, 2012·Physical Biology·Alex RheeAndre Levchenko
Apr 5, 2013·PLoS Computational Biology·Clive G BowsherPeter S Swain
Apr 23, 2013·Biophysical Journal·Michał KomorowskiMichael P H Stumpf
May 23, 2014·Current Opinion in Biotechnology·Clive G Bowsher, Peter S Swain
Jun 24, 2014·Seminars in Cell & Developmental Biology·Siobhan S Mc MahonMichael P H Stumpf
May 6, 2015·Statistical Applications in Genetics and Molecular Biology·Zhiyi Zhang, Lukun Zheng

❮ Previous
Next ❯

Citations

Sep 8, 2017·Royal Society Open Science·Eszter Lakatos, Michael P H Stumpf
Mar 18, 2016·Physical Review. E·Thomas R SokolowskiGašper Tkačik
Oct 9, 2019·Scientific Reports·Aaron Vazquez-Jimenez, Jesus Rodriguez-Gonzalez
Mar 20, 2018·Physical Review. E·Yoshihiko Hasegawa
Nov 13, 2020·Physical Biology·Anissa Guillemin, Michael P H Stumpf
Jul 9, 2021·Neoplasia : an International Journal for Oncology Research·Aurore Bugi-MarteynRastine Merat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Médecine sciences : M/S
Bertrand Jordan
Proceedings of the National Academy of Sciences of the United States of America
Andreas Hilfinger, Johan Paulsson
© 2021 Meta ULC. All rights reserved