Deflating the RNA Mg2+ bubble. Stereochemistry to the rescue!

BioRxiv : the Preprint Server for Biology
Pascal AuffingerL. D'Ascenso


Proper evaluation of the ionic structure of biomolecular systems remains challenging in X ray and cryo-EM techniques. Herein, we re-evaluate the model of the ribosome ionic structure proposed in a 2019 Nat. Commun. paper by A. Rozov et al. We suggest that neglecting stereochemical principles when evaluating ion binding features may result in misleading conceptions of the solvent structure of ribosomal particles. We propose an alternative interpretation of the crystallographic data that suggests that monovalent ions and not divalent ions are prevalent in the 1st solvation shell of ribosomes.

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