PMID: 8961034Nov 25, 1996Paper

Infradian mood fluctuations during a Major Depressive episode

Journal of Affective Disorders
F BenedettiE Smeraldi

Abstract

We investigated the predictability of infradian mood fluctuations during acute depressive episodes in patients affected by mood disorders. Previous findings showed that in a subgroup of patients the depressive symptomathology fluctuates with day-to-day changes which follow cyclical patterns (termed "minicycles'). We applied time series analysis, by means of autocorrelation techniques, to time lagged serial recordings of perceived mood levels of 22 inpatients (13 Major Depressive Recurrent and 9 Bipolar Depressive Disorders). Five patients (22.7%) were shown to exhibit predictable cyclical patterns in their perceived symptomathology, ranging in length from 6 to 14 days. Our study confirms the existence and the predictability, in a subgroup of patients, of cyclical mood patterns. Preliminary evidence suggests that patients with minicycles receive more medication changes than patients without, and thus that cyclical mood fluctuations strongly interacts with both the clinical decision making process and the outcome of acute depressive episodes.

References

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Citations

Jun 3, 1998·Journal of Affective Disorders·F BenedettiE Smeraldi
Jul 14, 1999·Journal of Affective Disorders·E LattuadaE Smeraldi
Nov 27, 2002·Psychiatry Research·Alessandro SerrettiEnrico Smeraldi
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Alessandro SerrettiDavid Rossini
Oct 21, 2005·Psychonomic Bulletin & Review·Thomas L Thornton, David L Gilden
May 22, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Paola ArtioliEnrico Smeraldi
Jul 21, 2004·Psychiatry Research·Alessandro SerrettiEnrico Smeraldi
Feb 28, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·William Sulis
Jan 10, 2018·Nature Communications·Maxime O BaudVikram R Rao
Mar 17, 2021·Nature Reviews. Neurology·Philippa J KarolyMaxime O Baud

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