Abstract
Appetitive behaviours occur in a state of behavioural and physiological activation that allows the optimal performance of these goal-directed behaviours. Here, we tested the hypothesis that histamine neurons under the command of the infralimbic cortex are important to provide behavioural activation. Extracellular histamine and serotonin were measured by microdialysis of the medial prefrontal cortex in behaving rats in parallel with a picrotoxin microinjection into the infralimbic cortex. The injection aroused the rats behaviourally, increased histamine release and decreased serotonin levels. Inhibition of the infralimbic cortex with muscimol produced the opposite effects on neurotransmitter release. The behavioural activation induced by motivating hungry rats with caged food was paralleled by an immediate histamine release, whereas awakening induced by tapping their microdialysis bowl increased serotonin, but not histamine levels. In conclusion, picrotoxin injection into the infralimbic cortex produces behavioural activation together with histamine release; in a similar manner, induction of an appetitive state produced histamine release, likely related to increased behavioural activation characteristic of an appetitive behaviour.
References
Sep 1, 1991·The Journal of Comparative Neurology·H EricsonC Köhler
Jan 1, 1989·Neuroscience and Biobehavioral Reviews·T W RobbinsB J Everitt
Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Dec 24, 1997·Brain Research. Brain Research Reviews·R C Pierce, P W Kalivas
Feb 2, 2000·Neuroscience and Biobehavioral Reviews·D S Zahm
Oct 12, 2000·Neuroscience Letters·O InzunzaF Torrealba
Jun 20, 2002·Neurobiology of Learning and Memory·Jean-Marc EdelineNathalie Cotillon
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Barbara E Jones
Aug 23, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Manuel Angeles-CastellanosCarolina Escobar
Feb 8, 2005·Nature Neuroscience·J AmatS F Maier
Feb 9, 2005·Behavioural Brain Research·Margarita M MeynardFernando Torrealba
Apr 29, 2005·Neuroscience·S BerrettaD Paré
May 5, 2005·The European Journal of Neuroscience·J L ValdésF Torrealba
Mar 24, 2006·The European Journal of Neuroscience·José Luis ValdésFernando Torrealba
Jan 17, 2007·Psychopharmacology·J D SalamoneS M Mingote
Feb 24, 2007·Psychopharmacology·Brian A Baldo, Ann E Kelley
Mar 6, 2007·Psychopharmacology·John D Salamone
Jul 26, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·George F Koob, Michel Le Moal
Aug 19, 2009·The European Journal of Neuroscience·Michael V BarattaSteven F Maier
Jun 10, 2010·The European Journal of Neuroscience·José Luis ValdésFernando Torrealba
Jul 20, 2010·Progress in Neurobiology·Christian BrabantEzio Tirelli
Feb 1, 2014·Physiology & Behavior·M E RiverosF Torrealba
Citations
Apr 26, 2017·Physiological Reports·Battuvshin Lkhagvasuren, Takakazu Oka
Feb 13, 2018·Frontiers in Neural Circuits·Xiao YuWilliam Wisden
Aug 22, 2018·British Journal of Pharmacology·Gustavo ProvensiMaria Beatrice Passani
Jul 19, 2019·Frontiers in Neuroscience·María E RiverosJosé L Valdés
Jun 28, 2018·Frontiers in Physiology·María E Riveros, Mauricio A Retamal