Infrared and Raman screening of seized novel psychoactive substances: a large scale study of >200 samples

The Analyst
L E JonesS E Bell

Abstract

The potential of IR absorption and Raman spectroscopy for rapid identification of novel psychoactive substances (NPS) has been tested using a set of 221 unsorted seized samples suspected of containing NPS. Both IR and Raman spectra showed large variation between the different sub-classifications of NPS and smaller, but still distinguishable, differences between closely related compounds within the same class. In initial tests, screening the samples using spectral searching against a limited reference library allowed only 41% of the samples to be fully identified. The limiting factor in the identification was the large number of active compounds in the seized samples for which no reference vibrational data were available in the libraries rather than poor spectral quality. Therefore, when 33 of these compounds were independently identified by NMR and mass spectrometry and their spectra used to extend the libraries, the percentage of samples identified by IR and Raman screening alone increased to 76%, with only 7% of samples having no identifiable constituents. This study, which is the largest of its type ever carried out, therefore demonstrates that this approach of detecting non-matching samples and then identifying them using s...Continue Reading

References

Feb 19, 2000·Forensic Science International : Synergy·N Sondermann, K A Kovar
Aug 8, 2007·Journal of Forensic Sciences·Steven E J BellSimon H Cosbey
Apr 18, 2009·Forensic Science International : Synergy·Hadir M MaherC Randall Clark
Mar 30, 2010·Journal of Forensic Sciences·Robert G Weston
Jul 12, 2011·Drug Testing and Analysis·H R SumnallJ McVeigh
Oct 1, 2011·Drug Testing and Analysis·Matthew J West, Michael J Went
Jan 9, 2013·Drug Testing and Analysis·Mathieu P ElieMark G Baron
Aug 1, 2013·Drug Testing and Analysis·R ChristieP Kavanagh
Jul 25, 2014·Forensic Science International : Synergy·Kenji TsujikawaHiroyuki Inoue
Nov 18, 2014·Expert Opinion on Drug Discovery·Urvi Gala, Harsh Chauhan

❮ Previous
Next ❯

Citations

Mar 7, 2017·Forensic Science International : Synergy·Amira GuirguisJacqueline L Stair
Sep 29, 2020·Journal of Forensic Sciences·Cui-Mei LiuZhen-Dong Hua
Jul 14, 2020·Frontiers in Chemistry·Bronislav JurásekMartin Kuchař
Dec 15, 2020·Journal of Analytical Toxicology·Joy EliaertsNele Samyn
Aug 5, 2021·Scientific Reports·Hiroyuki KawagoeKatsumasa Fujita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.