Infrared neural stimulation fails to evoke neural activity in the deaf guinea pig cochlea

Hearing Research
Alexander C ThompsonPaul R Stoddart

Abstract

At present there is some debate as to the processes by which infrared neural stimulation (INS) activates neurons in the cochlea, as the lasers used for INS can potentially generate a range of secondary stimuli e.g. an acoustic stimulus is produced when the light is absorbed by water. To clarify whether INS in the cochlea requires functioning hair cells and to explore the potential relevance to cochlear implants, experiments using INS were performed in the cochleae of both normal hearing and profoundly deaf guinea pigs. A response to laser stimulation was readily evoked in normal hearing cochlea. However, no response was evoked in any profoundly deaf cochleae, for either acute or chronic deafening, contrary to previous work where a response was observed after acute deafening with ototoxic drugs. A neural response to electrical stimulation was readily evoked in all cochleae after deafening. The absence of a response from optical stimuli in profoundly deaf cochleae suggests that the response from INS in the cochlea is hair cell mediated.

References

Feb 16, 2002·Audiology & Neuro-otology·R K Shepherd, N A Hardie
Mar 26, 2005·Optics Letters·Jonathon WellsAnita Mahadevan-Jansen
Jan 18, 2006·Journal of Biomedical Optics·Jonathon WellsAnita Mahadevan-Jansen
Jul 28, 2006·Lasers in Surgery and Medicine·Agnella D IzzoJoseph T Walsh
May 29, 2007·Biophysical Journal·Jonathon WellsE Duco Jansen
Jun 8, 2007·IEEE Transactions on Bio-medical Engineering·Agnella D IzzoClaus-Peter Richter
Jul 4, 2007·The Laryngoscope·Ingo Ulrik TeudtClaus-Peter Richter
Sep 4, 2009·Journal of Biomedical Optics·Gentiana I WenzelGuenter Reuter
Oct 16, 2009·Current Opinion in Neurobiology·Richard H KramerDirk Trauner
Jan 19, 2011·The Journal of Physiology·Gregory M DittamiRichard D Rabbitt
Jan 19, 2011·The Journal of Physiology·Suhrud M RajguruRichard D Rabbitt
Feb 1, 2011·IEEE Transactions on Bio-medical Engineering·Ingo Ulrik TeudtAndrej Kral
Mar 23, 2011·Nature Photonics·M W JenkinsA M Rollins
Sep 10, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew K WiseRobert K Shepherd
Mar 15, 2012·Nature Communications·Mikhail G ShapiroFrancisco Bezanilla
Mar 24, 2012·Journal of Neurophysiology·E S AlbertC Chabbert
Aug 17, 2012·Journal of Biomedical Optics·Alexander C ThompsonPaul R Stoddart
Jan 1, 2011·Laser & Photonics Reviews·Claus-Peter RichterJoseph T Walsh
Dec 18, 2012·Biomedical Optics Express·Michael SchultzAndrej Kral
Mar 9, 2013·Journal of Biomedical Optics·Alexander C ThompsonPaul R Stoddart
Jul 19, 2013·IEEE Transactions on Bio-medical Engineering·Alexander ThompsonPaul Stoddart
Aug 10, 2013·Journal of Visualized Experiments : JoVE·William G A BrownPaul R Stoddart
Sep 3, 2013·NeuroImage·Jonathan M CayceAnna W Roe
Oct 22, 2013·Biophysical Journal·Oluwarotimi Okunade, Joseph Santos-Sacchi
Feb 11, 2014·The Journal of Clinical Investigation·Victor H HernandezTobias Moser
Apr 18, 2014·Biophysical Journal·Qiang LiuRichard D Rabbitt
Apr 25, 2014·Biomedical Optics Express·Alexander RettenmaierGünter Reuter
Nov 25, 2014·Journal of Neural Engineering·Shefin S GeorgeJames B Fallon

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Citations

Nov 11, 2015·Otolaryngologic Clinics of North America·Sidharth V Puram, Daniel J Lee
Dec 15, 2016·Expert Opinion on Biological Therapy·Rachael T RichardsonKarina Needham
Jun 16, 2016·Scientific Reports·N KallweitH Maier
Sep 17, 2016·Scientific Reports·Janani S IyerKonstantina M Stankovic
Jul 15, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Takashi D Y Kozai, Alberto L Vazquez
Aug 28, 2015·Physiological Reports·Xiaodong TanClaus-Peter Richter
Sep 21, 2016·Network : Computation in Neural Systems·Robin S WeissWerner Hemmert
May 27, 2016·Journal of Neurophysiology·Richard D RabbittRebecca Lim
Dec 14, 2016·IEEE Transactions on Bio-medical Engineering·Nan XiaClaus-Peter Richter
Oct 17, 2018·Cold Spring Harbor Perspectives in Medicine·Tobias DombrowskiTobias Moser
Apr 1, 2020·EMBO Molecular Medicine·Alexander DieterTobias Moser
Jan 13, 2018·Scientific Reports·Xiaodong TanClaus-Peter Richter
Nov 7, 2018·Neurophotonics·Yingyue XuClaus-Peter Richter
Jul 1, 2020·EMBO Molecular Medicine·Alexander DieterTobias Moser
Mar 20, 2020·Physiological Reviews·Sonja KleinlogelTobias Moser
Aug 6, 2020·Healthcare Technology Letters·Rachael Theresa RichardsonJames B Fallon
Jan 22, 2021·Lasers in Surgery and Medicine·Aditi AgarwalClaus-Peter Richter
Nov 20, 2019·Otolaryngologic Clinics of North America·Elliott D KozinKonstantina M Stankovic
Jul 19, 2018·Molecular Therapy : the Journal of the American Society of Gene Therapy·Maria J DuarteDaniel J Lee
Mar 17, 2021·Journal of Neural Engineering·William G A BrownPaul R Stoddart
Apr 20, 2021·Laryngoscope Investigative Otolaryngology·Philip D Littlefield, Claus-Peter Richter
May 29, 2021·Scientific Reports·Rachael T RichardsonJames B Fallon
Oct 16, 2020·Journal of Neural Engineering·Z FeketeA Zátonyi

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