Infrared reflectometry of skin: Analysis of backscattered light from different skin layers

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Miguel PleitezWerner Mäntele

Abstract

We have recently reported infrared spectroscopy of human skin in vivo using quantum cascade laser excitation and photoacoustic or photothermal detection for non-invasive glucose measurement . Here, we analyze the IR light diffusely reflected from skin layers for spectral contributions of glucose. Excitation of human skin by an external cavity tunable quantum cascade laser in the spectral region from 1000 to 1245cm-1, where glucose exhibits a fingerprint absorption, yields reflectance spectra with some contributions from glucose molecules. A simple three-layer model of skin was used to calculate the scattering intensities from the surface and from shallow and deeper layers using the Boltzmann radiation transfer equation. Backscattering of light at wavelengths around 10μm from the living skin occurs mostly from the Stratum corneum top layers and the shallow layers of the living epidermis. The analysis of the polarization of the backscattered light confirms this calculation. Polarization is essentially unchanged; only a very small fraction (<3%) is depolarized at 90° with respect to the laser polarization set at 0°. Based on these findings, we propose that the predominant part of the backscattered light is due to specular reflecta...Continue Reading

Citations

Aug 18, 2017·Chemical Society Reviews·Andreas SchwaighoferBernhard Lendl
Jul 25, 2019·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Su Ji KimJaehyoun Ha
Mar 14, 2020·The Analyst·Shazzad RasselDayan Ban
Jun 28, 2020·Journal of Diabetes Science and Technology·Sven Delbeck, H Michael Heise
Jan 16, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Thomas G MayerhöferJürgen Popp
Mar 6, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Su Ji KimJun Bae Lee

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