Infrared spectral features of exfoliated cervical cells, cervical adenocarcinoma tissue, and an adenocarcinoma cell line (SiSo)

Gynecologic Oncology
Shanmugam NeviliappanP T Wong

Abstract

The objective of the present study is to evaluate and compare the infrared spectral features of normal and malignant exfoliated cervical cells, cells from malignant tissue, and the SiSo cell line. Infrared spectra of cervical adenocarcinoma (CA) tissue, normal and malignant exfoliated cervical cells, and a uterine cervical adenocarcinoma cell line (SiSo) were obtained. Spectral qualities in terms of band intensity ratio and band position, which reflect configurational changes in the functional groups of the above samples, were measured. Spectral bands of CA tissue, exfoliated cells from CA, and the cell line were similar but markedly different from that of exfoliated normal cervical cells. Significant changes in bands at 1025 cm(-1) (glycogen), 1080 cm(-1) (glycogen and nucleic acids), 1155 cm(-1) (C-OH groups of serine, threonine, and tyrosine of cell proteins, and C-O groups of carbohydrates), 1240 cm(-1) (PO(2) groups of nucleic acids), 1400 cm(-1) (methyl group of lipids and proteins), and 1450 cm(-1) (methylene group of lipids and proteins) were noted in the CA tissue, exfoliated CA cells, and adenocarcinoma cell line compared with exfoliated normal cells. Marked shifts in band positions from 1080 to 1086 cm(-1), 1153 to 1...Continue Reading

References

Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B RigasP T Wong

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Citations

Mar 25, 2006·Future Oncology·R K Sahu, S Mordechai
Nov 22, 2008·Journal of Biomedical Optics·Herculano da Silva MartinhoAirton Abrahão Martin
Jul 19, 2008·Analytical and Bioanalytical Chemistry·Katia WehbeCyril Petibois
Jul 22, 2008·Journal of Photochemistry and Photobiology. B, Biology·Kaustuv DasNicholas Stone
Aug 19, 2015·Analytical and Bioanalytical Chemistry·Fiona M LyngHugh J Byrne
Aug 29, 2006·Trends in Biotechnology·Cyril Petibois, Gérard Déléris
Apr 22, 2016·Journal of the Science of Food and Agriculture·Rong LiangJia Wang
Dec 3, 2008·Technology in Cancer Research & Treatment·F Bazant-HegemarkN Stone
Jun 30, 2004·Scandinavian Journal of Gastroenterology·R K SahuS Mordechai
Apr 2, 2016·Faraday Discussions·I R RamosF M Lyng
May 15, 2012·Reproductive Sciences·Ercan Bastu, John Yeh
Feb 4, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jacek PijankaJosep Sulé-Suso
Sep 13, 2003·World Journal of Gastroenterology : WJG·Jian-Sheng WangJin-Guang Wu
Oct 12, 2018·Scientific Reports·Radosław ChaberJózef Cebulski
Dec 18, 2020·Applied Spectroscopy·Kamila KochanBayden R Wood
Jun 13, 2021·Nature Protocols·Damien TraynorFiona M Lyng

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