Infrequent APC mutations in serrated adenoma

The Tohoku Journal of Experimental Medicine
R Dehari

Abstract

In 1990, Longacre and Fenoglio-Preiser introduced "serrated adenoma (SA)" combining architectural and cytological features of hyperplastic polyp and adenomatous epithelium. It has been reported that intramucosal carcinoma occurs in 10% of SAs. Although there have been many reports on SAs, its histogenesis and natural history still remain unknown. To clarify the genetic changes in SA, APC mutations in 28 SAs, 4 adenocarcinomas in/with SAs, 12 tubular adenomas (TAs) and 10 adenocarcinomas in/with TAs were evaluated in the present study. After polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) analyses, gene mutations were confirmed by direct sequencing. No APC mutation was detected in adenocarcinomas in/with SAs, and only one SA without adenocarcinoma (3.8%) was found to be positive for APC gene mutation, whereas the mutations were found in 66.7% of TAs and in 50% of adenocarcinomas in/with TAs. The frequency of APC gene mutation in SAs was significantly lower than that in control sporadic TAs. These findings suggest that SAs are genetically different from TAs.

References

Sep 17, 1992·Nature·S M PowellK W Kinzler
Jun 1, 1990·The American Journal of Surgical Pathology·T A Longacre, C M Fenoglio-Preiser
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jul 16, 1985·Biochemical and Biophysical Research Communications·S E GoelzB Vogelstein
May 7, 1993·Science·L A AaltonenS R Hamilton
May 26, 1998·Japanese Journal of Cancer Research : Gann·H UchidaS Baba
Jan 30, 1999·The Journal of Pathology·T HiyamaE Tahara

❮ Previous
Next ❯

Citations

May 5, 2009·Nature Immunology·Stefan TenzerAstrid K N Iversen
Nov 11, 2008·Nature Medicine·Angel Varela-RohenaJames L Riley
Dec 6, 2006·Immunology and Cell Biology·M L Munier, A D Kelleher
Jul 2, 2005·AIDS·Gillian C HarcourtUNKNOWN Hemophilia Growth and Development Study (HGDS)
Jun 26, 2007·AIDS·Piyush Tripathi, Suraksha Agrawal
Jul 16, 2002·Gut·E J SawyerI P M Tomlinson
Sep 30, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Xiangsheng FuYali Zhang
Feb 25, 2003·The American Journal of Pathology·Seun-Ja ParkTsung-Teh Wu
Apr 4, 2008·Cancer Science·Yutaka Suehiro, Yuji Hinoda
Apr 30, 2016·Scientific Reports·Chan Hyuk ParkChang Soo Eun
Aug 21, 2013·International Journal of Surgical Pathology·Yan ShiYu-Fei Jiao
Jun 25, 2009·Advances in Anatomic Pathology·Efsevia Vakiani, Rhonda K Yantiss
Sep 25, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Seung M DongKyoung-Mee Kim
Jun 15, 2017·The American Journal of Surgical Pathology·Taiki HashimotoNobuyoshi Hiraoka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.