Infrequent chemoradiation-induced acute esophagitis in the Asian population: A meta-analysis of published clinical trials for unresectable stage III non-small cell lung cancer

Thoracic Cancer
Takefumi KomiyaChao H Huang

Abstract

Severe (grade 3 or higher) esophagitis is one of the major toxicities for chemoradiation in the treatment of stage III non-small cell lung cancer (NSCLC). The difference among ethnic groups has never been investigated in detail. Prospective trials with concurrent platinum-containing chemoradiation in unresectable disease were investigated, and a total of 116 treatment arms with 7520 patients were identified. Univariate analysis demonstrated that treatment arms conducted in Asia had significantly lower incidence of severe esophagitis (170/2534, 6.7%, odds ratio 0.289) than in other nations (1025/4986, 20.6%). In the multivariable model, Asian/non-Asian ethnicity, multi-/single-agent, and split are jointly significant predictors after adjusting for all possible factors. This study suggests that severe esophagitis occurs less frequently in the Asian population compared to the non-Asian population.

References

Apr 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K FuruseS Negoro
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K FuruseY Ariyoshi
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne AupérinJean-Pierre Pignon
Sep 10, 2011·Journal of the National Cancer Institute·Walter J CurranJames D Cox
Oct 2, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jose Luis Lopez GuerraZhongxing Liao
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Sep 17, 2013·International Journal of Radiation Oncology, Biology, Physics·David A PalmaGeorge Rodrigues

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Citations

Jul 16, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Takefumi Komiya, Shana L Palla

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