Infusion of a combination of propofol and medetomidine for long-term anesthesia in ponies

American Journal of Veterinary Research
Regula Bettschart-WolfensbergerK W Clarke

Abstract

To determine the minimal infusion rate of propofol in combination with medetomidine for long-term anesthesia in ponies and the effects of atipamezole on recovery. 12 ponies. Ponies were sedated with medetomidine (7 microg/kg of body weight, IV). Ten minutes later, anesthesia was induced with propofol (2 mg/kg, IV). Anesthesia was maintained for 4 hours, using an infusion of medetomidine (3.5 microg/kg per hour, IV) and propofol at a rate sufficient to prevent ponies from moving after electrical stimulation. Arterial blood pressures and blood gas analysis, heart rates, and respiratory rates were monitored. For recovery, 6 ponies were given atipamezole (60 microg/kg, IV). Induction and recovery were scored. Minimal propofol infusion rates ranged from 0.06 to 0.1 mg/kg per min. Mean arterial blood pressure was stable (range, 74 to 86 mm Hg), and heart rate (34 to 51 beats/min) had minimal variations. Variable breathing patterns were observed. Mean PaO2 (range, 116 to 146 mm Hg) and mean PaCO2 (range, 48 to 51 mm Hg) did not change significantly with time, but hypoxemia was evident in some ponies (minimal PaO2, 47 mm Hg). Recovery was fast and uneventful with and without atipamezole (completed in 20.2 and 20.9 minutes, respectively...Continue Reading

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Citations

Sep 19, 2001·American Journal of Veterinary Research·R Bettschart-WolfensbergerK W Clarke
Dec 11, 2003·Journal of the American Veterinary Medical Association·Guilherme M Mendes, André L Selmi
Apr 19, 2006·Journal of the American Veterinary Medical Association·Mohammed A UmarWilliam W Muir
Sep 23, 2014·The Veterinary Journal·María VillalbaIgnacio A Gómez de Segura
Nov 5, 2016·Journal of Veterinary Emergency and Critical Care·Dorothee C HeidenreichBarbara M Kirby
Feb 11, 2009·The Veterinary Clinics of North America. Equine Practice·Ann E Wagner
Feb 16, 2006·Veterinary Anaesthesia and Analgesia·Alma A Garcia LascurainEnrique Núñez Hernandez
Dec 5, 2009·The Journal of Veterinary Medical Science·Kazuto YAMASHITAWilliam W MUIR
Dec 7, 2013·Journal of Feline Medicine and Surgery·Thierry BethsKirby Pasloske
Sep 6, 2006·The Journal of Veterinary Medical Science·Kazuomi OkuToru Fujinaga
Jul 20, 2010·Equine Veterinary Journal·E VettoratoR E Clutton
Jul 6, 2005·The Journal of Veterinary Medical Science·Kazuomi OkuToru Fujinaga
Oct 13, 2012·The Journal of Veterinary Medical Science·Tomohito IshizukaWilliam W Muir
Nov 21, 2014·The Journal of Veterinary Medical Science·Mohammed Ahmed UmarKazuto Yamashita
Jan 18, 2005·Equine Veterinary Journal·R Bettschart-WolfensbergerK W Clarke
Jul 11, 2012·Journal of Veterinary Pharmacology and Therapeutics·A de VriesJ W Sear
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Miguel Gozalo-Marcilla, Simone Katja Ringer
Nov 22, 2005·Veterinary Anaesthesia and Analgesia·Regula Bettschart-WolfensbergerAnton Fürst

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