Infusion of cytotoxic T lymphocytes for the treatment of viral infections in hematopoetic stem cell transplant patients.

Current Opinion in Infectious Diseases
Katherine A BaughAnn M Leen

Abstract

Allogeneic hematopoietic stem cell transplantation has proven curative for a range of malignant and nonmalignant disorders. However, the clinical success of this therapy is marred by the morbidity associated with viral infections, which are frequent (cytomegalovirus 15.6-28%, adenovirus 3-21%, BK virus 18.5-20.7%) post-transplant. These infections occur as a consequence of transplant conditioning regimens designed to eliminate not only malignant cells but also host immune cells that might interfere with stem cell engraftment. The result is a transient period of immune compromise when hematopoietic stem cell transplant recipients are at risk of infectious complications associated with both latent (cytomegalovirus, Epstein-Barr virus, BK virus, human herpes virus 6, herpes simplex virus, varicella-zoster virus) and community-acquired viruses including adenovirus, respiratory syncytial virus, and parainfluenza virus. Current standard of care for many of these infections involves pharmacologic agents, which are often ineffective and associated with side effects including nephrotoxicity and hepatotoxicity. Ultimately, because these agents do not address the underlying immune compromise, viral rebound often occurs. Thus, a number of ...Continue Reading

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Citations

Oct 1, 2019·Current Opinion in Infectious Diseases·Natalie J M Dailey GarnesAya Aboulhosn
Feb 8, 2019·Journal of Hematology & Oncology·Theresa KaeuferleTobias Feuchtinger
Oct 9, 2019·Current Opinion in Oncology·Gaurav Sutrave, David J Gottlieb
Oct 16, 2018·Current Opinion in Infectious Diseases·Marjorie V BatistaRoy F Chemaly
Sep 13, 2019·Clinical Microbiology Reviews·Michael G Ison, Hans H Hirsch
Jan 9, 2019·Frontiers in Microbiology·Diego R HijanoRandall T Hayden
Mar 11, 2020·Frontiers in Immunology·Valérie JanelleJean-Sébastien Delisle
Jun 23, 2019·Current Hematologic Malignancy Reports·Wei JiangEmily Blyth
Dec 18, 2021·Seminars in Respiratory and Critical Care Medicine·Joseph P Lynch, Adriana E Kajon

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Methods Mentioned

BETA
leukapheresis

Software Mentioned

CliniMACS Prodigy Cytokine Capture System

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