Infusion of dipeptides as nutritional substrates for glutamine, tyrosine, and branched-chain amino acids in patients with acute pancreatitis

Metabolism: Clinical and Experimental
R SteiningerK Langer

Abstract

In this study we investigated the effect of a total parenteral nutrition supplemented with synthetic dipeptides on plasma and muscle amino acid metabolism in four patients with acute pancreatitis. We infused an amino acid solution containing alanylglutamine, glycylglutamine, glycylvaline, glycylisoleucine, glylcylleucine, and glycyltyrosine for a period of five days in daily dosages of 10.3, 22.1, 68.8, 37.2, 42.5, and 15.7 mmol, respectively. The plasma levels remained below 100 mumol/L for all infused dipeptides. The plasma concentrations of alanylglutamine were not measurable. Mean peptide urine excretion remained below 5%, with the exception of glycylglutamine (8.5% +/- 5.1%). Arteriovenous concentration differences of the dipeptides across the leg were not significantly different from zero, indicating that the infused dipeptides have no important role in the nitrogen exchange of skeletal muscle. A marked intracellular glutamine deficiency in skeletal muscle was found in all four patients (5.1 +/- 0.6 mmol/L v 19.5 +/- 0.8 in healthy subjects) before infusion. Intracellular glutamine concentration was significantly higher after the infusion period (5.1 +/- 0.7 v 9.5 +/- 1.8 mmol/L, P greater than .05), but no normalization ...Continue Reading

Citations

Jun 1, 1993·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·P Fürst, P Stehle
Sep 12, 2000·Current Gastroenterology Reports·D J Nompleggi
Nov 1, 1994·The Proceedings of the Nutrition Society·F R Backwell
Jul 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·P G RadmacherD H Adamkin
Mar 1, 1996·The British Journal of Surgery·J C HallR McCauley
Jul 4, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Concepción F EstívarizThomas R Ziegler
Jun 1, 1993·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·J A VazquezS A Adibi
Jan 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·P Fürst

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