Infusion of esmolol attenuates lipopolysaccharide-induced myocardial dysfunction

The Journal of Surgical Research
Zenggeng WangChunli Yang

Abstract

Myocardial depression, as a well-recognized manifestation of cardiac dysfunction, often accompanies severe sepsis and septic shock. Inflammation-induced myocardial apoptosis is key to the development of sepsis-induced cardiac dysfunction. Increasing evidence suggests the anti-inflammatory role of β1-adrenergic blocker, esmolol, during lethal endotoxemia. However, the direct protective effect of esmolol on cardiomyocyte viability during sepsis is still not clear. Here, we aimed to study whether infusion of esmolol can directly inhibit myocardial apoptosis during lipopolysaccharide (LPS)-triggered inflammatory insult. C57BL/6 mice were randomized into four groups as follows: control; esmolol infusion; LPS insult; and esmolol infusion + LPS insult. Function of left ventricle was assessed by invasive hemodynamics at 6 h after LPS insult. Terminal deoxynucleotidyl transferase mediated dUTP nick end labeling (TUNEL) staining, caspase-3 expression level, and the Bcl-2/Bax ratio were used to evaluate myocardial apoptosis at 6 h after LPS insult or esmolol infusion. Administration of LPS resulted in significant decrease in left ventricular end-systolic pressure, reduced maximal rate of change of left ventricular pressure, and the increa...Continue Reading

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Citations

Feb 2, 2017·Journal of Intensive Care Medicine·Jason A Ferreira, Brittany D Bissell
Jun 29, 2016·Intensive Care Medicine·Daniel A ReuterArmand Mekontso Dessap
Dec 17, 2019·Journal of Cardiothoracic and Vascular Anesthesia·Alessandro BellettiSilvia Ajello

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