PMID: 3768222Oct 1, 1986Paper

Infusion of midazolam in paediatric patients after cardiac surgery

British Journal of Anaesthesia
A R Lloyd-Thomas, P D Booker

Abstract

Midazolam was given, by infusion, for the sedation of 10 children receiving intensive care after cardiac surgery. Plasma concentrations greater than 250 ng ml-1 were required for adequate sedation. Midazolam did not cumulate in eight of the 10 children, and these patients excreted the drug in a fashion similar to that by adults. However, midazolam did accumulate in two children, one with profound hepatic disturbance. In one of these patients recovery was slow following cessation of the infusion.

Citations

Jan 1, 1989·European Journal of Clinical Pharmacology·K PayneT Dawes
Mar 13, 2002·Journal of Pain and Symptom Management·Christine ChengJose Pereira
Jun 7, 2003·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Beverly PringleAllen Eskenazi
Jul 29, 2003·Anesthesiology·Hussain MullaDavid Robert Upton
Feb 1, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hussain MullaDavid R Upton
Feb 6, 1999·Critical Care Medicine·L FonsmarkP Carl
Jul 9, 2003·Critical Care Medicine·S N de WildtJ N van den Anker
Feb 4, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mary E HartmanScott R Schulman
Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·G R ParkP Ferenci
Jan 1, 1997·Archives of Disease in Childhood·L ShekerdemianA Redington
Apr 4, 2014·International Journal of Pediatrics·Gian Maria Pacifici
Sep 10, 2005·Pediatric Annals·Joseph D Tobias
Mar 1, 1990·Journal of Clinical Anesthesia·S HennebergM P Persson
May 1, 1989·British Journal of Clinical Pharmacology·G R ParkS Dawling
May 1, 1989·British Journal of Clinical Pharmacology·M P ShellyG R Park
Nov 1, 1993·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G R Park
Oct 5, 2014·Archives of Disease in Childhood·Mohammed I AltamimiImti Choonara
Jan 9, 1999·Journal of Child Neurology·J M Pellock
Dec 1, 2004·Therapeutic Drug Monitoring·Frank BremerJürgen Schüttler
Jan 25, 2005·Therapeutic Drug Monitoring·Saskia N de WildtJohn N van den Anker
Mar 1, 1995·The Journal of Bone and Joint Surgery. American Volume·C D VarelaT L Schmidt
Jun 1, 1993·The Annals of Pharmacotherapy·A MooreI Choonara
Dec 1, 1993·The Annals of Pharmacotherapy·C M Marx, M D Reed
Jan 1, 1996·The Annals of Pharmacotherapy·J HughesI Choonara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.