Infusion of tumor necrosis factor (TNF) causes an increase in circulating TNF-binding protein in humans

M LantzI Olsson


Serum samples from cancer patients receiving intravenous infusions of recombinant tumor necrosis factor (rTNF) and recombinant interferon-gamma (rIFN-gamma) were analyzed for TNF and the TNF-binding protein (TNF-BP). TNF-BP is a soluble fragment of the transmembrane TNF receptor with antagonistic effects to TNF and is released by proteolytic cleavage of the receptor. During a 60-min infusion of rTNF, peak serum levels of rTNF were observed after 30 to 60 min and a transient increase of circulating TNF-BP was observed with peak levels between 30 and 120 min. Injection of IFN-gamma alone did not affect the levels of TNF and TNF-BP. Thus administration of rTNF leads to release into the circulation of TNF-BP, which may modulate both systemic and local effects of TNF and influence its therapeutic efficacy.


Jan 1, 1995·Transplant International : Official Journal of the European Society for Organ Transplantation·J F LeeuwenbergWim A Buurman
Jul 8, 2009·Rheumatology International·Y ValleJosé Francisco Muñoz-Valle
Jun 19, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A S MouraM O C Rocha
Mar 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J ViacA Claudy
Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·W McGuireD Kwiatkowski
Feb 1, 1997·Molecular Aspects of Medicine·W H Fridman, E Tartour
Jul 29, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hiroshi YagiMartin L Yarmush
May 22, 2010·Nature Reviews. Drug Discovery·Denise Faustman, Miriam Davis
Feb 16, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J Raju, R P Bird
Feb 24, 2001·Journal of the American Geriatrics Society·P E MarikNORASEPT II Study Investigators. North American Sepsis Trial II
Nov 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·D A Joyce, J H Steer
Feb 21, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Fang-Chi HsuHealth ABC Study
Jan 1, 1996·Microbiology and Immunology·D HoberP Wattré
Sep 1, 1993·Clinical and Experimental Immunology·A KalinkovichZ Bentwich
Dec 31, 1997·British Journal of Obstetrics and Gynaecology·B C SheuS C Huang
Oct 1, 1994·American Journal of Reproductive Immunology : AJRI·S J FortunatoK F Swan
Mar 9, 2005·Gut·T GustotD Franchimont
Mar 5, 2005·Ophthalmic Research·Necip TorunUwe Pleyer
Sep 12, 2012·American Journal of Nephrology·Marijn M SpeeckaertJoris R Delanghe
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Juanita H VernooyEmiel F Wouters
Jan 30, 2004·Psychosomatic Medicine·Sally S DickersonJohn L Fahey


Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Apr 1, 1988·The Journal of Experimental Medicine·P SeckingerJ M Dayer
Jan 1, 1987·Cancer Chemotherapy and Pharmacology·K KimuraH Majima
Apr 15, 1987·Klinische Wochenschrift·R Munker, H P Koeffler
Jan 1, 1987·Cancer Chemotherapy and Pharmacology·P J CreavenA Proefrock

Related Concepts

Tumor Necrosis Factor-alpha
Tumor Necrosis Factor Receptor
Proteins, Recombinant DNA
Cytokinesis of the Fertilized Ovum
Integral to Membrane
Proteolytic Enzyme
Binding Protein

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.