Infusion with an oxytocin receptor antagonist delays parturition in a marsupial

Journal of Reproduction and Fertility
M B RenfreeG Shaw

Abstract

The oxytocin receptor antagonist [1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Om]-oxytocin (Atosiban) is a specific antagonist of both mesotocin- and oxytocin-induced myometrial contractions in late pregnant tammars in vitro. Continuous intravenous infusion of Atosiban (1 mg kg-1 day-1) for 3 or 7 days from day 24 of the 26.5 day gestation significantly delayed births. In both the 3 day and 7 day infusion groups, all 15 control animals were pregnant and gave birth within the normal time (day 26.75 +/- 0.20, mean +/- SEM), during the infusion of saline. The neonates weighed 387 +/- 8 mg. Deliveries were observed in 15 Atosiban-treated animals significantly (P < 0.05) later than in the controls (day 27.85 +/- 0.19; neonate weight 413 +/- 9 mg). All pouch young were successfully suckled, even in the continued presence of Atosiban. Baseline plasma concentrations of the prostaglandin F metabolite (PGFM) in pregnant tammars were < 200 pg ml-1. A surge in plasma PGFM occurred at birth (811 +/- 116 pg ml-1), followed by a rapid fall to baseline concentrations within 1 h after birth. This was observed both in saline- and in Atosiban-treated animals that gave birth during the observation period, and did not differ significantly between the treatment...Continue Reading

Citations

Jul 22, 1998·Animal Reproduction Science·L T SebastianM B Renfree
May 24, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Andrew M Blanks, Steven Thornton
Apr 28, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Andrew L SiebelLaura J Parry
May 5, 2000·Experimental Physiology·L J Parry, R A Bathgate
Jul 24, 2004·Animal Reproduction Science·G Jenkin, I R Young
Sep 2, 2003·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Claudia FreyerMarilyn B Renfree
Feb 13, 2010·Cold Spring Harbor Protocols·Danielle HickfordMarilyn B Renfree

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