Infusions of naloxone into the medial preoptic area, ventromedial nucleus of the hypothalamus, and amygdala block conditioned place preference induced by paced mating behavior

Hormones and Behavior
S Patricia García-HorsmanRaúl G Paredes

Abstract

Paced mating induces positive affect as revealed by conditioned place preference (CPP) in female rats. It has been suggested that endogenous opioids are involved in the generation of this positive affect since systemic administration of the opioid antagonist naloxone blocks mating-induced CPP. Several brain structures, including the medial preoptic area (mPOA), the ventromedial nucleus of the hypothalamus (VMH), the amygdala (Me), and the nucleus accumbens (Acb) have been implicated in the control of female sexual behavior. However, it is not known if these structures also participate in the positive affect produced by paced mating. To this end we determined the effects of intracranial administration of naloxone methiodide into the mPOA, VMH, Me and Acb on conditioned place preference induced by paced mating in female rats. Regardless of the site of infusion 5 micro of naloxone did not affect any of the sexual behavior parameters measured during copulation. When CPP was evaluated, the groups infused with naloxone into the mPOA, the VMH, and the Me before each conditioning session did not develop place preference. Only the group infused with naloxone in the Acb and the control groups did so. These results demonstrate that opioid...Continue Reading

Citations

Jun 3, 2009·Behavioral Neuroscience·Sarah H Meerts, Ann S Clark
Jan 1, 2012·Socioaffective Neuroscience & Psychology·Kevin S Holloway
Jan 1, 2012·Socioaffective Neuroscience & Psychology·Genaro A Coria-Avila
Jul 1, 2013·Sexual Medicine Reviews·Lesley MarsonUrsula Wesselmann
Mar 15, 2016·Frontiers in Neuroscience·Nancy M UndaRaúl G Paredes
Sep 8, 2010·Hormones and Behavior·Dulce Ma ArzateRaúl G Paredes
Oct 6, 2009·Physiology & Behavior·Francisco J CamachoRaúl G Paredes
Oct 2, 2009·Peptides·Richard J Bodnar
Jun 13, 2009·Hormones and Behavior·Mayte ParadaJames G Pfaus
May 7, 2009·Behavioural Brain Research·Wendy Portillo, Raúl G Paredes
Mar 2, 2010·Physiology & Behavior·Tamara Cibrian-LlanderalGenaro A Coria-Avila
Nov 10, 2010·Physiology & Behavior·Pedro Paredes-RamosGenaro A Coria-Avila
Aug 4, 2009·Hormones and Behavior·Francisco J CamachoRaúl G Paredes
Jun 30, 2011·Hormones and Behavior·Rebeca CoronaRaúl G Paredes
Nov 2, 2016·Socioaffective Neuroscience & Psychology·James G PfausGenaro A Coria-Avila
Oct 7, 2017·Integrative and Comparative Biology·Jeremy A Spool, Lauren V Riters
Aug 29, 2018·Journal of Feline Medicine and Surgery·Lingna ZhangJohn McGlone
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Dec 12, 2018·Hormones and Behavior·Moriah R ArnoldSarah H Meerts
Nov 3, 2009·Behavioural Brain Research·Ana Lúcia CecconelloGilberto Luiz Sanvitto

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