Ingenol Mebutate Gel 0.05% in the Treatment of Anogenital Warts: A Prospective Controlled Trial Comparing It With Topical Podophyllin Solution 25.

Sexually Transmitted Diseases
Mohammad Shahidi DadrasNikoo Mozafari

Abstract

Anogenital warts (AGWs) are a common therapeutic challenge. All therapies are associated with burning, pain, and frustrating high rate of recurrence. The search for a new alternative continues. Recently, a diterpene ester extracted from the Euphorbia peplus plant (ingenol mebutate [IM]) has been shown to possess activity against AGWs. This study aimed to compare and evaluate the therapeutic efficacy and safety of topical 0.05% ingenol gel with another herbal extract medication (topical 25% podophyllin solution) in treatment of AGWs. This was a comparative single blinded nonrandomized, 2-arm trial of ingenol 0.05% gel versus podophyllin solution 25% administered up to 6 times to patients with AGWs. To evaluate the therapeutic efficacy, the complete clearance rate and recurrence rate were assessed 1 and 12 weeks after last treatment, respectively. Safety was assessed by occurrence and severity of pain and local skin reaction (LSR). Of 31 and 36 patients in the IM group and podophyllin group who completed the study, initial complete resolution was observed in 20 (64.5%) and 14 (38.9%) patients, respectively (P = 0.03). The initial clearance was faster in the IM group (2.00 ± 0.91 weeks) compared with the podophyllin group (4.21 ± ...Continue Reading

References

Nov 21, 2001·Sexually Transmitted Infections·G von Krogh, E Longstaff
Mar 14, 2002·Journal of Ethnopharmacology·Kavita Vermani, Sanjay Garg
Jun 25, 2008·International Journal of STD & AIDS·Christina StefanakiAndreas Katsambas
Mar 14, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·C J N LaceyJ Ross
Mar 31, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·R E Schopf
Jun 28, 2015·Molecular Cancer Therapeutics·Sandra N FreibergerGünther F L Hofbauer
Sep 24, 2015·BMC Research Notes·Bruna De FeliceMassimo Nacca
Dec 4, 2015·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·William A BowerUNKNOWN Centers for Disease Control and Prevention (CDC)
May 18, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Stephan Alexander Braun, Peter Arne Gerber
May 31, 2016·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Stephan Alexander Braun, Peter Arne Gerber
Aug 16, 2016·Dermatology : International Journal for Clinical and Investigative Dermatology·Mosab T Mohanna, Günther F L Hofbauer
Dec 3, 2016·Annals of Dermatology·Yu Seok JungGyong Moon Kim
Oct 13, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·H K LarsenM Haedersdal
May 26, 2018·Sexually Transmitted Diseases·Stephan A BraunPeter A Gerber
Nov 22, 2018·Clinical and Experimental Dermatology·J Magdaleno-TapialP Hernández-Bel

❮ Previous
Next ❯

Citations

Jul 1, 2020·Dermatologic Therapy·Mohammad Shahidi DadrasNikoo Mozafari
Sep 22, 2021·International Journal of STD & AIDS·Mohammad Shahidi-DadrasNikoo Mozafari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.