Ingenol mebutate gel for actinic keratosis: the link between quality of life, treatment satisfaction, and clinical outcomes

Journal of the American Academy of Dermatology
Matthias AugustinC William Hanke

Abstract

Actinic keratosis therapy can elicit unsightly and painful local skin responses; assessment of treatment satisfaction and health-related quality of life (QoL) is important. Ingenol mebutate gel is a novel topical field therapy for actinic keratosis. Post-hoc analyses were performed based on patient-reported outcomes from phase-III trials (n = 1005) to assess the effects of ingenol mebutate on QoL and the relationship between both QoL and treatment satisfaction, and degree of lesion clearance. Patients received ingenol mebutate or vehicle for self-application to a 25-cm(2) contiguous area: 0.015% once daily for 3 consecutive days (face/scalp) or 0.05% once daily for 2 consecutive days (trunk/extremities). QoL (Skindex-16) and Treatment Satisfaction Questionnaire for Medication data were recorded. Significant, positive associations between Treatment Satisfaction Questionnaire for Medication score and degree of clearance were identified for patients in the face/scalp (effectiveness P < .0001 and global satisfaction P = .0002) and trunk/extremities (P < .0001 and P = .0014, respectively) groups. There was a significant association between Skindex-16 score and clearance for patients in the face/scalp group for change in symptoms (P ...Continue Reading

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Citations

Nov 3, 2015·Expert Opinion on Drug Safety·Brian Berman
Apr 8, 2016·The Journal of Dermatological Treatment·William C HankeStephen Stone
Jun 1, 2016·The Journal of Dermatological Treatment·Ángeles FlórezCarlos de la Torre
Nov 1, 2016·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·T Hommel, R-M Szeimies
Mar 7, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·R Cerio
Aug 4, 2018·Expert Opinion on Drug Metabolism & Toxicology·Eggert Stockfleth, Mike Bastian
Jul 1, 2017·The Journal of Dermatological Treatment·Hanna NorrlidGunnel Ragnarson Tennvall
Oct 27, 2017·World Journal of Clinical Oncology·Nevena SkrozaConcetta Potenza
Oct 12, 2018·International Journal of Dermatology·Eleni AnthonySaxon D Smith
Feb 3, 2021·Dermatologic Therapy·Ayman GradaGiovanni Damiani
Apr 10, 2021·Expert Opinion on Drug Safety·Elias A T KochMarkus V Heppt

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