PMID: 9160341Feb 1, 1997Paper

Ingested IFN-alpha has biological effects in humans with relapsing-remitting multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
S A BrodJ S Wolinsky

Abstract

Parenterally administered human recombinant type I interferons (hrIFN) in relapsing-remitting multiple sclerosis (RRMS) decrease relapses and spontaneous in vitro IFN-gamma production, reduce clinical progression, and decrease magnetic resonance imaging (MRI)-defined disease activity and lesions. Parenterally administered type I IFN use is limited by clinical and chemical toxicities, and the induction of antibodies that abrogate their activity in vivo correlated with the loss of clinical benefit. Therefore, we determined whether ingested IFN-alpha was non-toxic and had biological effects in humans. Ingested hrIFN-alpha showed no toxicity in normal volunteers or patients with RRMS at doses ranging from 300 to 100,000 units. In subjects with RRMS, a significant decrease in Con A-mediated proliferation and serum soluble intercellular adhesion molecule-1 (sICAM-1), a surrogate measure for disease activity in MS, was found after ingesting 10,000 and 30,000 units IFN-alpha The RRMS subjects also showed decreased IL-2 secretion after ingesting 10,000 units IFN-alpha and decreased IFN-gamma, TGF-beta and IL-10 production after ingesting 30,000 units IFN-alpha. The decreased secretion of IFN-gamma and IL-2 by ingested IFN-alpha suggests...Continue Reading

References

Dec 1, 1992·Journal of Interferon Research·P L WittE C Borden
Mar 1, 1991·Immunology Today·T R Mosmann, K W Moore
Jul 1, 1985·The Journal of Experimental Medicine·J KimK Bottomly
Dec 1, 1985·Annals of Neurology·A NoronhaB G Arnason
Mar 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·B H Waksman, W E Reynolds
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jan 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·G UzéK E Mogensen
Jan 1, 1993·Annual Review of Immunology·K W MooreT R Mosmann
Jan 1, 1995·Duodecim; lääketieteellinen aikakauskirja·M PaneliusJ Ruutiainen
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACS, J LINDENMANN
Mar 31, 1965·Annals of the New York Academy of Sciences·E C ALVORDM W KIES

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Citations

Nov 20, 2003·Journal of Autoimmunity·S L Kirk, S J Karlik
Jun 7, 2000·Pharmaceutical Science & Technology Today·M W Beilharz
Jan 19, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S A BrodW J Riley
Feb 13, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Staley A Brod
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·W A Tompkins
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S A Brod
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J M CumminsS Krakowka
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·V Bocci
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M Tanaka-KataokaM Kurimoto
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Y SatohT Minagawa
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S TakayamaM Kurimoto
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J K SmithJ Cummins
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J K SmithS L Berk
Feb 25, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·W R FleischmannC M Fleischmann
Jul 27, 1999·Cytokine·S A BrodJ S Wolinsky
May 21, 1999·Multiple Sclerosis : Clinical and Laboratory Research·P F Smith, C L Darlington
Apr 1, 2004·Endocrinology and Metabolism Clinics of North America·Kevan C Herold
Jan 2, 2007·Journal of Neuroimmunology·Staley A Brod, Zachary Hood
Jan 28, 2010·Pharmaceuticals·Manfred W BeilharzJoseph M Cummins
Jun 14, 2000·Transplantation·S A BrodS Stepkowski
Feb 5, 2005·American Journal of Veterinary Research·Joseph M CumminsChad G Thompson
Aug 21, 2003·Multiple Sclerosis : Clinical and Laboratory Research·C PolmanUNKNOWN European Oral Interferon Beta-1a in Relapsing-Remitting MS Study Group
Dec 18, 2002·Experimental Biology and Medicine·Staley A Brod
Dec 5, 1998·Clinical Immunology and Immunopathology·F M RollwagenN D Pacheco
Nov 27, 2007·Journal of Neuroimmunology·Staley A Brod, Zachary M Hood

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