Ingestion and killing of Listeria monocytogenes by blood and milk phagocytes from mastitic and normal cattle.

Journal of Clinical Microbiology
C J CzuprynskiR D Schultz

Abstract

Human listeriosis resulting from consumption of listeria-contaminated dairy products is emerging as a significant public health concern. There is a need to understand better the processes involved in the pathogenesis of Listeria monocytogenes-induced bovine mastitis. In the present report, we describe the results of the in vitro interaction of L. monocytogenes with bovine blood and milk leukocytes. Induction of an experimental L. monocytogenes mastitis resulted in a rapid and dramatic increase in neutrophils in the milk of infected cows. Blood neutrophils and mononuclear cells and milk leukocytes from listeria-infected and uninfected cows readily ingested L. monocytogenes in the presence of serum opsonins. These leukocytes also killed a portion of the ingested listeriae. Ingestion of listeriae evoked a vigorous chemiluminescence response by blood neutrophils and a relatively weak response by blood mononuclear cells. Ingestion, killing, and chemiluminescence by milk leukocytes were directly related to the percentage of neutrophils that were present. Blood neutrophils from healthy donor cattle ingested and killed L. monocytogenes when leukocyte-depleted milk and whey from mastitic cows were the sole sources of opsonins, although ...Continue Reading

References

Mar 1, 1977·Cellular Immunology·J W Smith, R D Schultz
Oct 1, 1977·The Journal of Infectious Diseases·P K PetersonP G Quie
Jul 1, 1977·Veterinary Pathology·K M Charlton, M M Garcia
Jul 1, 1975·Applied Microbiology·J Weis, H P Seeliger
Feb 1, 1986·Applied and Environmental Microbiology·P S HayesD W Fleming
Jul 1, 1987·Applied and Environmental Microbiology·M P DoyleR D Schultz
Feb 1, 1988·Applied and Environmental Microbiology·V K BunningJ T Tierney
Dec 1, 1985·Journal of Medical Microbiology·J C Anderson, M R Williams
Feb 1, 1985·Infection and Immunity·S P Targowski, W Klucinski
Feb 14, 1985·The New England Journal of Medicine·D W FlemingA L Reingold
Feb 14, 1985·The New England Journal of Medicine·M Barza
Nov 1, 1985·Infection and Immunity·C J Czuprynski, H L Hamilton
Jan 1, 1974·The Journal of Clinical Investigation·R T SteigbigelJ S Remington
May 1, 1972·The Journal of Experimental Medicine·F C Lane, E R Unanue
Jun 1, 1966·Bacteriological Reviews·M L Gray, A H Killinger
Oct 1, 1984·Journal of Leukocyte Biology·R W Godfrey, M S Wilder
Jan 27, 1983·The New England Journal of Medicine·W F SchlechC V Broome
Sep 1, 1984·Antimicrobial Agents and Chemotherapy·A SavoiniD Romeo
Oct 25, 1980·The Veterinary Record·M GitterP H Blampied
Jul 1, 1954·The Journal of Infectious Diseases·J W OSEBOLD, T INOUYE

❮ Previous
Next ❯

Citations

Jan 26, 2013·Animal Health Research Reviews·Keith P Poulsen, Charles J Czuprynski
Apr 17, 2016·Environmental Microbiology Reports·Juan J QueredaM Graciela Pucciarelli
Sep 1, 1991·Microbiological Reviews·J M Farber, P I Peterkin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.