Ingestion of an Inulin-Enriched Pork Sausage Product Positively Modulates the Gut Microbiome and Metabolome of Healthy Rats

Molecular Nutrition & Food Research
Rebekka ThøgersenHanne Christine Bertram

Abstract

Processed meat intake is associated with a potential increased colorectal cancer (CRC) risk. In contrast, dietary fiber consumption has been found to lower CRC risk, possibly via mechanisms involving the gut microbiota (GM) and its metabolites. This study investigates the effect of inulin enrichment of a common pork sausage product on GM composition and activity in healthy rats. Thirty Sprague-Dawley rats are fed a diet based on either an inulin-enriched sausage (n = 12), a corresponding control sausage without enrichment (n = 12), or a standard chow diet (n = 6) during a 4 week intervention. NMR-based metabolomics analyses are conducted on fecal and plasma samples, and GM composition is determined using 16S rRNA gene amplicon sequencing. Pronounced effects of diets on GM composition and activity are found. Rats fed the inulin-enriched sausages have increased levels of short chain fatty acids (SCFAs) in the fecal and plasma metabolome and increased fecal levels of Bifidobacterium spp. as compared to rats fed sausages without enrichment. Inulin enrichment of a meat product resembles general effects seen upon dietary fiber consumption and corroborates that healthier processed meats can be developed through strategic inclusion of ...Continue Reading

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Citations

Feb 23, 2020·Nature Reviews. Gastroenterology & Hepatology·Lorne J HofsethFranklin G Berger
Aug 6, 2020·International Journal of Molecular Sciences·Federica PerilloFederica Facciotti
Dec 24, 2018·Foods·Carolina Cortés-HerreraFabio Granados-Chinchilla
Dec 6, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Xiali QinHailong Cao
Oct 20, 2020·Microbial Pathogenesis·Amir Hossein MohseniXiangsheng Fu

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