Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth

Developmental Cell
Qi LiY Tony Ip

Abstract

The intestinal epithelium has a high cell turnover rate and is an excellent system to study stem cell-mediated adaptive growth. In the Drosophila midgut, the Ste20 kinase Misshapen, which is distally related to Hippo, has a niche function to restrict intestinal stem cell activity. We show here that, under low growth conditions, Misshapen is localized near the cytoplasmic membrane, is phosphorylated at the threonine 194 by the upstream kinase Tao, and is more active toward Warts, which in turn inhibits Yorkie. Ingestion of yeast particles causes a midgut distention and a reduction of Misshapen membrane association and activity. Moreover, Misshapen phosphorylation is regulated by the stiffness of cell culture substrate, changing of actin cytoskeleton, and ingestion of inert particles. These results together suggest that dynamic membrane association and Tao phosphorylation of Misshapen are steps that link the mechanosensing of intestinal stretching after food particle ingestion to control adaptive growth.

Citations

Jun 23, 2020·EMBO Reports·Maja C FunkMichael Boutros
Dec 20, 2018·Annual Review of Biochemistry·Shenghong MaKun-Liang Guan
Dec 14, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Rachel K ZwickOphir D Klein
Aug 24, 2018·Nature·Zhipeng MengKun-Liang Guan
Jul 23, 2019·F1000Research·Willem-Jan PannekoekMartijn Gloerich
Dec 4, 2019·Nature Cell Biology·Rui ChenKun-Liang Guan
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Yong Suk Cho, Jin Jiang
May 29, 2021·Journal of Cellular Physiology·Kyoung Moo ChoiDaniel J Tschumperlin
Jun 11, 2021·Frontiers in Cell and Developmental Biology·Xiaomin CaiZhipeng Meng
Jul 16, 2021·Seminars in Cancer Biology·Fu-Long Li, Kun-Liang Guan

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