Ingredients, Anti-Liver Cancer Effects and the Possible Mechanism of DWYG Formula Based on Network Prediction

OncoTargets and Therapy
Yao LiXin Zhou

Abstract

Hepatitis virus infection plays a critical role in liver cancer initiation and development; so the purpose of this study was to investigate the anti-liver cancer effects of DiWuYangGan (DWYG) which was effective for hepatitis. Network predictions were performed. Next, several tests, including HPLC, Caco-2 absorption models, MMT, protein chip, Western blotting and H22-tumor-bearing mouse, were carried out to investigate the effects and possible mechanism of DWYG. Network results showed DWYG might be involved in some processes such as STAT cascade. Some target genes may correspondingly participate in these procedures, such as IL-6, CASP3, AKT1, PPAR, and TP53. Diseases associated with DWYG formula may be liver cancer and hepatitis. Potential active compounds might be CUR and ISO. Chemical analysis results showed that ingredients in the formula, including DEO, SCHB, SOLA, SOLB, SCHA, LIQ, ISO, POT, and CHL, could be determined, indicating that DWYG samples for the following experiments were controllable and consistent. Caco-2 absorption of ingredients in DWYG, including DEO, SCHB, SOLA, SOLB, and LIQ, worked very well. In vitro experiment results showed that DWYG could inhibit the growth of cell lines and its effective ingredients...Continue Reading

References

Aug 16, 2008·Journal of Chromatography. a·Qingying Zhang, Min Ye
Nov 26, 2009·Nucleic Acids Research·Feng ZhuYuZong Chen
Nov 26, 2010·Nucleic Acids Research·Hao YeZhiwei Cao
Dec 29, 2010·Cell Research·Guobin He, Michael Karin
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Nov 15, 2011·Nucleic Acids Research·Michael KuhnPeer Bork
Aug 30, 2017·Molecular Medicine Reports·Silvia YumnamGon Sup Kim
Oct 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shenshen YangYubo Li

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Methods Mentioned

BETA
ELISA
chip

Software Mentioned

SPSS
DAVID

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