inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

Science
A BanerjeeW R Jacobs

Abstract

Isoniazid (isonicotinic acid hydrazide, INH) is one of the most widely used antituberculosis drugs, yet its precise target of action on Mycobacterium tuberculosis is unknown. A missense mutation within the mycobacterial inhA gene was shown to confer resistance to both INH and ethionamide (ETH) in M. smegmatis and in M. bovis. The wild-type inhA gene also conferred INH and ETH resistance when transferred on a multicopy plasmid vector to M. smegmatis and M. bovis BCG. The InhA protein shows significant sequence conservation with the Escherichia coli enzyme EnvM, and cell-free assays indicate that it may be involved in mycolic acid biosynthesis. These results suggest that InhA is likely a primary target of action for INH and ETH.

Associated Clinical Trials

Jan 23, 2017·Roberto D OliveiraRoberto D Oliveira

References

Oct 1, 1992·Journal of General Microbiology·H BerglerF Turnowsky
Jan 11, 1991·Methods in Enzymology·W R JacobsB R Bloom
Mar 15, 1992·The New England Journal of Medicine·D E Snider, W L Roper
Aug 1, 1991·PCR Methods and Applications·F Barany
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G V KalpanaW R Jacobs
Dec 1, 1989·Journal of Bacteriology·F TurnowskyG Högenauer
Dec 1, 1973·Antimicrobial Agents and Chemotherapy·D Saroja, K P Gopinathan
Jun 1, 1971·Journal of General Microbiology·F G WinderD Whelan
Sep 1, 1970·Journal of General Microbiology·F G Winder, P B Collins
Feb 25, 1993·The New England Journal of Medicine·T R FriedenS W Dooley

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Citations

Feb 1, 1996·Pediatric Pulmonology·L S Inselman
Apr 12, 2002·Chembiochem : a European Journal of Chemical Biology·M NguyenB Meunier
Nov 1, 1994·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C B Inderlied
Jan 20, 2009·Cellular and Molecular Life Sciences : CMLS·R P Massengo-Tiassé, J E Cronan
Sep 17, 2013·Applied Microbiology and Biotechnology·Giovanna RiccardiClaudia Binda
Nov 29, 2007·Pflügers Archiv : European journal of physiology·David AlsteensYves F Dufrêne
Sep 26, 2009·Journal of Molecular Modeling·Ashutosh Kumar, Mohammad Imran Siddiqi
Aug 23, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H J MarttilaH Soini
Mar 1, 2009·Indian Journal of Microbiology·Varalakshmi D VissaPatrick J Brennan
Jul 12, 1996·Biochimica Et Biophysica Acta·C O Rock, J E Cronan
Aug 1, 1996·Molecular Aspects of Medicine·M J Colston
Mar 1, 1994·Research in Microbiology·A E Suzuki, J M Inamine
Jan 1, 1996·Research in Microbiology·N Rastogi, J O Falkinham
Jan 1, 1996·Research in Microbiology·J C Sacchettini, J S Blanchard
Jan 1, 1996·Research in Microbiology·A Telenti, D H Persing
Oct 1, 1994·Trends in Microbiology·S T Cole
Jul 1, 1996·Trends in Microbiology·C E Barry, K Mdluli
Nov 1, 1996·Trends in Microbiology·Y Zhang
Oct 14, 2003·Bioorganic & Medicinal Chemistry Letters·Min ChuVincent Gullo
Jan 22, 2004·Current Opinion in Immunology·Masahiko SugitaMichael B Brenner
Sep 11, 2013·European Journal of Medicinal Chemistry·Christophe MenendezMichel Baltas
Oct 16, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Nilanjan ChakrabortyShubhashish Kamal Guha
Dec 13, 2003·Tuberculosis·Clare V SmithJames C Sacchettini
Jan 7, 1998·Biochemical Pharmacology·C E Barry
Nov 9, 2000·FEBS Letters·T FawcettA R Slabas
Jun 25, 2002·Journal of Molecular Biology·Martin Cohen-GonsaudAnnaïk Quemard
Oct 10, 2001·Progress in Lipid Research·R J HeathC O Rock
Nov 26, 1998·Progress in Lipid Research·C E BarryY Yuan
Mar 29, 2003·Diagnostic Microbiology and Infectious Disease·Maria J TorresJavier Aznar
Apr 3, 2001·International Journal of Antimicrobial Agents·S H Gillespie

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