PMID: 7544960Sep 1, 1995Paper

Inhalation anesthetics inhibit the release of endothelium-derived hyperpolarizing factor in the rabbit carotid artery

Anesthesiology
V LischkeM Hecker

Abstract

Inhalation anesthetics may interfere with the synthesis or action of endothelium-derived vasoactive factors. We investigated the effects of desflurane, enflurane, halothane, isoflurane, and sevoflurane on the release of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the isolated endothelium-intact carotid artery of the rabbit. Isolated segments of the carotid artery were suspended in Krebs-Henseleit solution (37 degrees C) and preconstricted with phenylephrine (1 microM). Relaxations caused by acetylcholine (ACh) (0.03-10 microM) or sodium nitroprusside (0.01-10 microM) were compared in the presence or absence of the nitric oxide synthase inhibitor NG-nitro-L-arginine (0.1 mM) in segments exposed to desflurane (8%), enflurane (2-4%), halothane (2-3.5%), isoflurane (2-4%), or sevoflurane (2%) as well as in NG-nitro-L- arginine-treated segments exposed to enflurane (2%) in combination with the KCa(+)-channel blocker tetrabutylammonium (0.3 mM) or the cytochrome P450 inhibitor clotrimazole (3 microM). Desflurane, enflurane, and sevoflurane selectively inhibited the ACh-induced release of EDHF. Halothane and isoflurane also weakly affected the nitric oxide-mediated relaxant response to ACh. The inhibitory eff...Continue Reading

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Citations

Dec 17, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H IranamiK Mizumoto
Nov 14, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y OshimaT Sato
Jul 14, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·J YoshinoS Takahashi
Mar 18, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Michel Félétou, Paul M Vanhoutte
Apr 11, 2000·Acta Anaesthesiologica Scandinavica·E HaddadB Vallet
Apr 12, 2000·Acta Physiologica Scandinavica·U PohlT Gloe
Oct 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F M Faraci, C G Sobey
Oct 1, 1996·Journal of Cardiovascular Pharmacology·H OishiK Tomokuni
Jan 22, 1998·Journal of Cardiovascular Pharmacology·P KesslerV B Schini-Kerth
Nov 21, 1997·Acta Anaesthesiologica Scandinavica·A Klockgether-RadkeG Hellige
Jan 23, 2016·Anesthesia and Analgesia·José A AguirreMichael Zaugg
Mar 12, 2016·Pflügers Archiv : European journal of physiology·Kasper Moller Boje RasmussenCharlotte Mehlin Sorensen
May 25, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sota OkamotoTatsuya Ichinohe
Dec 13, 2007·Anesthesiology·Noboru TodaYoshio Hatano
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
May 26, 2005·Anesthesiology·Robert M BryanSean P Marrelli

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