Inhalation of an ethanol-based zileuton formulation provides a reduction of pulmonary adenomas in the A/J mouse model.

AAPS PharmSciTech
K KarlageP B Myrdal

Abstract

Potential efficacy of zileuton, a 5-LOX inhibitor, was evaluated for the reduction of pulmonary adenomas in the A/J murine model when administered via nose-only inhalation. Development of pulmonary adenomas was induced with benzo(a)pyrene. Animals were treated with a zileuton solution (5 mg/mL in 85:15 ethanol/water) either twice weekly or five times a week via nose-only inhalation; The placebo solution (85:15 EtOH/H2O, no active) was also evaluated. Dose delivered was calculated to be 1.2 mg/kg per exposure for each zileuton group. After 20 weeks of treatment, surface tumors were enumerated and histologically assessed. A significant reduction in tumor count was noted for both the twice weekly administration (40%) and the five times a week administration (59%). The data also showed a significant reduction for the group, which received the placebo (approximately 58%). The treatment groups were also found to have an impact on the histological stages of adenoma development.

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Citations

Nov 6, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Juna V KonomiLou Ann S Brown
Apr 18, 2019·AAPS PharmSciTech·Usir S YounisPaul B Myrdal
Jun 12, 2013·Acta Biochimica Et Biophysica Sinica·Kausik Bishayee, Anisur Rahman Khuda-Bukhsh

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