Inhalation of Cedrus atlantica essential oil alleviates pain behavior through activation of descending pain modulation pathways in a mouse model of postoperative pain

Journal of Ethnopharmacology
Daniel F MartinsA R S dos Santos

Abstract

Cedrus atlantica essential oil (CaEO) presents analgesic and anti-inflammatory sedative properties. However, it remains unknown whether CaEO alleviates acute postoperative pain. Here, we investigated the effect of CaEO on postoperative pain and its mechanisms related to the descending pain control in Swiss males mice induced by a plantar incision surgery (PIS) in the hindpaw. Inhalation of CaEO (5', 30' or 60') markedly reduced mechanical hypersensitivity. This effect was prevented by pre-treatment with naloxone or p-chlorophenylalanine methyl ester (PCPA, 100mg/kg, i.p.)-induced depletion of serotonin. In addition, p-alpha-methyl-para-tyrosin (AMPT, 100mg/kg, i.p.)-induced depletion of norepinephrine, intraperitoneal injection of the α2-adrenergic receptor antagonist yohimbine (0.15 mg/kg, i.p.) or haloperidol (1mg/kg, i.p.) an antagonist of dopaminergic (D1 and D2) receptors prevented the effect of CaEO on hypersensitivity. These findings suggest that CaEO alleviates postoperative pain by activating the descending pain modulation pathways on the opioidergic, serotonergic, noradrenergic (α2-adrenergic) and dopaminergic (dopamine D1 and D2 receptors) systems.

References

Jun 1, 1993·Journal of Pharmaceutical Sciences·G BuchbauerH Dietrich
Feb 24, 1998·Clinics in Dermatology·C R Lovell
Jun 22, 1999·Journal of Holistic Nursing : Official Journal of the American Holistic Nurses' Association·J L Robins
May 30, 2002·Progress in Neurobiology·Mark J Millan
Mar 18, 2003·Journal of Ethnopharmacology·M Ira ThabrewL Senaratne
Sep 26, 2003·Anesthesiology·Esther M Pogatzki, Srinivasa N Raja
Mar 17, 2004·Neuroscience and Biobehavioral Reviews·G F Gebhart
Aug 18, 2005·Journal of Neurophysiology·Peggy Mason
Oct 13, 2006·Progress in Neurobiology·Antti Pertovaara
Jun 2, 2010·Current Neuropharmacology·David M MarksChi-Un Pae
Nov 23, 2011·International Journal of Food Microbiology·Wei-Cai ZengHong Gao
Jul 11, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Daniel F MartinsAdair R S Santos
Nov 30, 2012·Medicine and Science in Sports and Exercise·Mauricio P CunhaAna Lúcia S Rodrigues
Oct 30, 2013·Frontiers in Pharmacology·Katerina S IwaszkiewiczSusan Hua
Feb 4, 2014·European Journal of Pharmacology·Kamalakannan PanduranganRamaswamy Subramanyan

❮ Previous
Next ❯

Citations

Jun 30, 2016·International Immunopharmacology·Diogo V FonsêcaReinaldo N Almeida
Dec 26, 2016·Peptides·Richard J Bodnar
Feb 3, 2018·Pain Reports·Esther M Pogatzki-ZahnStephan A Schug
Aug 11, 2018·Pflügers Archiv : European journal of physiology·Leidiane Mazzardo-MartinsDaniel Fernandes Martins
Jun 9, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Scott A JohnsonKathryn Allred
Nov 19, 2020·International Journal of Molecular Sciences·Savitha DhandapaniIn-Cheol Jang
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Fan HuangNu-Man Tsai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.