Nov 1, 2018

Inhalation of marijuana affects Drosophila heart function

BioRxiv : the Preprint Server for Biology
Ivana GomezPaola Ferrero

Abstract

Medical uses of marijuana have been recently approved in many countries, and after a long ban on research, there is despicable scientific evidence regarding its action and side effects. We investigated the effect of inhalation of vaporized marijuana on cardiac function in Drosophila melanogaster , a suitable genetic model for assessing cardiovascular function. Chronic exposure of adult flies to vaporized marijuana reduces heart rate, increments contractility and prolongs relaxation. These changes are manifested in the cardiomyocytes with no effect in calcium handling, and in the absence of the canonical cannabinoids receptors identified in mammals. Our results are the first evidence of the in vivo impact of phytocannabinoids in D. melanogaster and open new paths for genetic screenings using vaporized compounds, providing a simple and affordable platform prior to mammalian models.

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Mentioned in this Paper

Cannabinoids
In Vivo
Calcium [EPC]
Research
Calcium
Genetic Screening (Procedure)
Cardiovascular System Function
Drosophila
Adverse Effects
Cannabis sativa plant

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