Inhalation of Staphylococcus aureus enterotoxin A induces IFN-gamma and CD8 T cell-dependent airway and interstitial lung pathology in mice.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Guruprasaadh MuralimohanAnthony T Vella

Abstract

Staphylococcus aureus, a primary source of bacterial superantigen (SAg), is known to colonize the human respiratory tract and has been implicated in airway inflammation. Studies have documented a role for SAgs in respiratory disorders, such as nasal polyps, chronic obstructive pulmonary disease, chronic rhinosinusitis, and asthma. However, cellular and molecular mediators involved in SAg-mediated pulmonary disease have not been clearly identified. In this study, we investigated the effect of intranasal staphylococcal enterotoxin A (SEA) exposure on murine lung. The pathological features in the lung resulting from SEA exposure had characteristics of both obstructive and restrictive pulmonary disorders. There was also an increase in bronchoalveolar lavage protein concentration and cellularity following SEA challenge. Massive CD8(+)Vbeta3(+) T cell accumulation observed in the lung was dependent on CD4 T cell help, both for recruitment and for IFN-gamma synthesis. The primary source of IFN-gamma synthesis was CD8 T cells, and depletion of these cells abrogated disease. IFN-gamma deficiency also prevented SEA-mediated disease, and this was by enhancing early recruitment of neutrophils as detected in the bronchoalveolar lavage. Thus...Continue Reading

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Citations

Apr 28, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jill A PooleDebra J Romberger
Jul 31, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fabienne VenetAlfred Ayala
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Soo Mun NgoiAnthony T Vella
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May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia SvedovaAnthony T Vella
Jun 14, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyle T Wright, Anthony T Vella
May 6, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Julia SvedovaAnthony T Vella
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Jan 13, 2018·Frontiers in Cellular and Infection Microbiology·Ana P Ferreira-DuarteIvani A DeSouza
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Nov 13, 2014·American Journal of Respiratory and Critical Care Medicine·Naeun LeeInsoo Kang

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