Abstract
Staphylococcus aureus, a primary source of bacterial superantigen (SAg), is known to colonize the human respiratory tract and has been implicated in airway inflammation. Studies have documented a role for SAgs in respiratory disorders, such as nasal polyps, chronic obstructive pulmonary disease, chronic rhinosinusitis, and asthma. However, cellular and molecular mediators involved in SAg-mediated pulmonary disease have not been clearly identified. In this study, we investigated the effect of intranasal staphylococcal enterotoxin A (SEA) exposure on murine lung. The pathological features in the lung resulting from SEA exposure had characteristics of both obstructive and restrictive pulmonary disorders. There was also an increase in bronchoalveolar lavage protein concentration and cellularity following SEA challenge. Massive CD8(+)Vbeta3(+) T cell accumulation observed in the lung was dependent on CD4 T cell help, both for recruitment and for IFN-gamma synthesis. The primary source of IFN-gamma synthesis was CD8 T cells, and depletion of these cells abrogated disease. IFN-gamma deficiency also prevented SEA-mediated disease, and this was by enhancing early recruitment of neutrophils as detected in the bronchoalveolar lavage. Thus...Continue Reading
References
Sep 19, 1979·The Journal of Experimental Medicine·J C Unkeless
Jan 1, 1991·Annual Review of Immunology·A HermanA M Pullen
Jan 1, 1993·Annual Review of Cell Biology·M T SchererP Marrack
Jul 1, 1995·The Journal of Investigative Dermatology·D Y LeungD A Norris
Sep 1, 1993·The Journal of Clinical Investigation·D Y LeungH A Sampson
Mar 1, 1993·The Journal of Investigative Dermatology·D Y LeungD A Norris
Nov 1, 1996·Infection and Immunity·R VabulasT Miethke
Apr 4, 1998·The Journal of Experimental Medicine·T Proft, J Fraser
Mar 26, 1999·European Journal of Immunology·U HerzH Renz
Feb 15, 2000·Clinical and Experimental Dermatology·L Skov, O Baadsgaard
Feb 26, 2000·Molecular Medicine Today·J FraserT Proft
May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Oct 21, 2000·FEMS Microbiology Letters·J M YarwoodP M Schlievert
Oct 6, 2001·Critical Care Medicine·L GeertsH Slegers
Nov 13, 2001·Allergy·K BreuerT Werfel
Jan 31, 2002·Annual Review of Medicine·Lee Maddox, David A Schwartz
Mar 29, 2002·Current Allergy and Asthma Reports·Claus BachertPaul van Cauwenberge
Oct 9, 2003·Current Allergy and Asthma Reports·Claus BachertPaul Van Cauwenberge
Nov 12, 2003·Emerging Infectious Diseases·Thomas ProftJohn D Fraser
Jun 22, 2005·Journal of Bacteriology·Willem B van LeeuwenAlex van Belkum
Sep 9, 2005·The Laryngoscope·Kristin A SeiberlingRobert C Kern
Jan 24, 2006·Infection and Immunity·Govindarajan RajagopalanChella S David
Aug 16, 2006·Seminars in Respiratory and Critical Care Medicine·Lorraine B Ware
Aug 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P W HellingsC Bachert
May 17, 2007·Current Allergy and Asthma Reports·Elizabeth A JacobsenJames J Lee
May 3, 2008·International Archives of Allergy and Immunology·Guruprasaadh MuralimohanAnthony T Vella
Citations
Apr 28, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jill A PooleDebra J Romberger
Jul 31, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fabienne VenetAlfred Ayala
Jul 1, 2010·Toxins·Sanjeev KumarAnthony T Vella
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Soo Mun NgoiAnthony T Vella
Jul 30, 2016·Scientific Reports·Li XiaoHuabin Li
Jun 23, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P J Barnes
May 28, 2011·Respiratory Research·Wouter HuvenneTania Maes
Jan 17, 2013·Mucosal Immunology·S KumarA T Vella
Jul 14, 2012·PloS One·Antoine MénoretAnthony T Vella
Jun 21, 2011·Immunological Reviews·Peter J Barnes
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia SvedovaAnthony T Vella
Jun 14, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyle T Wright, Anthony T Vella
May 6, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Julia SvedovaAnthony T Vella
Oct 19, 2017·Nature Communications·Paulus MrassJudy L Cannon
Jan 13, 2018·Frontiers in Cellular and Infection Microbiology·Ana P Ferreira-DuarteIvani A DeSouza
Feb 15, 2019·Frontiers in Immunology·Leili JiaHongbin Song
Jan 15, 2011·International Immunology·Jeremy P McAleerAnthony T Vella
Oct 29, 2015·PloS One·Antoine MénoretAnthony T Vella
Mar 12, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dalize M Squebola-ColaEdson Antunes
Nov 13, 2014·American Journal of Respiratory and Critical Care Medicine·Naeun LeeInsoo Kang
Jun 17, 2018·Mucosal Immunology·Antoine MénoretAnthony T Vella