Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung

The European Respiratory Journal
E AndréM Wjst

Abstract

High levels of particulate matter in ambient air are associated with increased respiratory and cardiovascular health problems. It has been hypothesised that it is the ultrafine particle fraction (diameter <100 nm) that is largely responsible for these effects. To evaluate the associated mechanisms on a molecular level, the current authors applied an expression profiling approach. Healthy mice were exposed to either ultrafine carbon particles (UFCPs; mass concentration 380 microg x m(-3)) or filtered air for 4 and 24 h. Histology of the lungs did not indicate any pathomorphological changes after inhalation. Examination of the bronchoalveolar lavage fluid revealed a small increase in polymorphonuclear cell number (ranging 0.6-1%) after UFCP inhalation, compared with clean air controls, suggesting a minor inflammatory response. However, DNA microarray profile analysis revealed a clearly biphasic response to particle exposure. After 4 h of inhalation, mainly heat shock proteins were induced, whereas after 24 h, different immunomodulatory proteins (osteopontin, galectin-3 and lipocalin-2) were upregulated in alveolar macrophages and septal cells. In conclusion, these data indicate that inhalation of ultrafine carbon particles trigge...Continue Reading

Citations

Feb 5, 2010·International Archives of Occupational and Environmental Health·Monika GubeThomas Kraus
Feb 9, 2012·International Archives of Occupational and Environmental Health·P BrandM Gube
Aug 4, 2007·Chemical Research in Toxicology·W James WaldmanPrabir K Dutta
Oct 1, 2008·Environmental Engineering Science·Barry DellingerRalf Zimmermann
Mar 13, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·John W HollowayIan A Yang
Dec 18, 2012·American Journal of Physiology. Cell Physiology·Rongsong LiTzung Hsiai
Jul 22, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey W CardEarle R Nestmann
Feb 24, 2009·American Journal of Respiratory and Critical Care Medicine·James M SametRobert B Devlin
Mar 28, 2008·American Journal of Respiratory Cell and Molecular Biology·Rodney L RouseArthur L Penn
Mar 1, 2015·Toxicology and Applied Pharmacology·Vasanthi R SunilDebra L Laskin
Apr 20, 2012·Biochimica Et Biophysica Acta·Subhankar ChakrabortySurinder K Batra
Feb 4, 2012·Experimental and Molecular Pathology·Agnieszka J ConnorDebra L Laskin
Sep 18, 2007·Regulatory Toxicology and Pharmacology : RTP·Werner I HagensAdriënne J A M Sips
Jun 11, 2009·Scandinavian Journal of Immunology·M SamuelsenM Løvik
May 12, 2010·Journal of Thrombosis and Haemostasis : JTH·A KhandogaF Krombach
Apr 25, 2014·Particle and Fibre Toxicology·Marianne GeiserHolger Schulz
Sep 25, 2007·Mutation Research·Banalata SenDavid M DeMarini
Jul 8, 2014·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Gao ZengShu-Bin Guo
Mar 20, 2010·Human & Experimental Toxicology·Martin RoursgaardSøren T Larsen
Oct 25, 2013·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Yuh-Chin T Huang
Jan 11, 2017·Particle and Fibre Toxicology·Christine SattlerTobias Stoeger
Jul 31, 2021·Journal of Hazardous Materials·Katherine R LandwehrUNKNOWN WAERP

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.