Inhalation toxicity assessment of carbon-based nanoparticles

Accounts of Chemical Research
Yasuo MorimotoManabu Shimada

Abstract

Although the demand for nanomaterials has grown, researchers have not conclusively determined the effects of nanomaterials on the human body. To understand the effects of nanomaterials on occupational health, we need to estimate the respiratory toxicity of nanomaterials through inhalation studies, intratracheal instillation studies, and pharyngeal aspiration studies. The discrepancies observed among these studies tend to result from differences in the physiochemical properties of nanomaterials, such as aggregation and dispersion. Therefore, in all toxicity studies, identification of the physicochemical properties of nanomaterials is essential. This Account reviews the inhalation toxicity of manufactured nanomaterials and compares them with inhalation and intratracheal instillation studies of well-characterized fullerene and carbon nanotubes. In many reports, pulmonary inflammation and injury served as pulmonary endpoints for the inhalation toxicity. To assess pulmonary inflammation, we examined neutrophil and macrophage infiltration in the alveolar and/or interstitial space, and the expression of the neutrophil and/or monocyte chemokines. We also reported the release of lactate dehydrogenase (LDH) and alkaline phosphatase (ALP)...Continue Reading

References

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Citations

Oct 1, 2013·Nihon eiseigaku zasshi. Japanese journal of hygiene·Yasuo MorimotoToru Takebayashi
Jun 12, 2013·Advanced Drug Delivery Reviews·Kunal BhattacharyaBengt Fadeel
Aug 7, 2014·Journal of Immunology Research·Yasuo MorimotoEtsushi Kuroda
Jan 15, 2016·Biochimica Et Biophysica Acta·Alexander P Lyubartsev, Alexander L Rabinovich
Oct 10, 2013·Inhalation Toxicology·Yasuo MorimotoHeinrich Ernst
Apr 22, 2015·Applied Biochemistry and Biotechnology·Karolina Werengowska-CiećwierzGerhard Rychlicki
Jun 13, 2015·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Yukiko YoshiuraYasuo Morimoto
Aug 11, 2017·Journal of Occupational Health·Norihiro KobayashiYasuo Morimoto
Mar 22, 2014·Chemical Society Reviews·Yi ZhangBing Yan
Apr 15, 2020·Journal of Occupational and Environmental Hygiene·Patrick O'ShaughnessyRalph Altmaier
Dec 30, 2015·Journal of Applied Toxicology : JAT·Naohide ShinoharaJunko Nakanishi
Oct 26, 2018·Particle and Fibre Toxicology·Taisuke TomonagaYasuo Morimoto
May 16, 2020·Frontiers in Bioengineering and Biotechnology·Ravikumar B ShindePandiaraj Manickam
Jun 30, 2015·Nanomaterials·Puja KhannaGyeong Hun Baeg
Jun 21, 2017·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Melisa Bunderson-SchelvanRaymond F Hamilton
Jan 24, 2020·ACS Applied Materials & Interfaces·Zhuang TangQi-Long Wang

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