Inhalation toxicity of brevetoxin 3 in rats exposed for 5 days

Journal of Toxicology and Environmental Health. Part a
Janet BensonDaniel Baden

Abstract

Brevetoxins are potent neurotoxins produced by the marine dinoflagellate Karenia brevis. Exposure to brevetoxins may occur during a K. brevis red tide when the compounds become aerosolized by wind and surf. This study assesses possible adverse health effects associated with short-term inhalation exposure to brevetoxin 3. Male F344/Crl/Br rats were exposed to 500 microg brevetoxin 3/m3 by nose-only inhalation for 0.5 or 2 h/d for 5 consecutive days. Control rats were sham exposed for 2 h to vehicle. Calculated deposited brevetoxin doses were 8.3 and 33 microg/kg/d for the low- and high-dose groups, respectively. At the termination of exposures, only body weights of the high-dose group (Group B) were significantly below control values. By immunohistochemistry (IHC), small numbers of splenic and peribronchiolar lymphoid tissue macrophages stained positive for brevetoxin, while nasal mucosa, liver, and brain were IHC negative for brevetoxin. No gross or microscopic lesions were observed in any tissue examined. There was no biochemical evidence of cytotoxicity or inflammation in bronchoalveolar lavage fluid. Alveolar macrophages showed some evidence of activation following brevetoxin exposure. Humoral-mediated immunity was suppresse...Continue Reading

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Citations

Jun 9, 2006·Journal of Toxicology and Environmental Health. Part a·Brad M TibbettsJanet M Benson
Jan 18, 2011·Journal of Toxicology and Environmental Health. Part a·Janet M BensonThomas H March
May 4, 2005·Environmental Health Perspectives·Janet M BensonDaniel G Baden
Nov 15, 2013·Toxins·Rex Munday, John Reeve
Oct 18, 2006·Inhalation Toxicology·Xiuzhen YanThomas F Murray
Jul 27, 2010·International Journal of Hygiene and Environmental Health·Kelli M Sas, John E Baatz
Jan 11, 2011·Harmful Algae·Lora E FlemingDaniel G Baden
Jan 12, 2010·Aquatic Toxicology·Catherine J WalshClarence Colle
Nov 26, 2008·Toxicon : Official Journal of the International Society on Toxinology·Catherine J WalshRichard H Pierce
Oct 3, 2006·Toxicon : Official Journal of the International Society on Toxinology·Janet M BensonDaniel G Baden
Feb 24, 2009·PloS One·David A JessupRaphael M Kudela
Feb 3, 2006·Natural Product Reports·John W BluntMichèle R Prinsep
Jan 24, 2018·Toxicon : Official Journal of the International Society on Toxinology·Ophelie PierreRaphaele Le Garrec

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