Inhalation toxicology of fumed dodecanediamine

Inhalation Toxicology
R ValentineG Kennedy

Abstract

Dodecanediamine (DDDA) is used in the production of specialty polymers. Exposure to this chemical was associated with dermal sensitization in pilot-plant workers, and the possibility that the chemical could produce dermal sensitization was confirmed in a guinea pig test. This property and its dermal irritative properties demonstrate the need to limit skin contact. The possibility of exposure via inhalation also exists. Although stable under ambient conditions, DDDA is processed at elevated temperatures where it may fume, forming a carbamate after reaction with atmospheric carbon dioxide. Some of the carbamate may be converted back to the diamine after hydrolysis in tissue. The rat was used to evaluate the effects of both acute and repeated exposure following inhalation. Fumed DDDA was found to be moderately toxic following a single 4-h exposure with lethality seen at concentrations of 680 mg/m3 or higher. Rats were then exposed to concentrations of either 0 (control), 11, 34, or 98 mg fumed DDDA/m3, 6 h/day, 5 days/wk for 2 wk. Mortality was seen at the highest concentrations, along with increased lung weights. In these rats, laryngeal and tracheal lesions consisting of acute necrosis and inflammation were seen, but surviving r...Continue Reading

References

Oct 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·F R JohannsenG K Hogan
Jan 1, 1980·Drug and Chemical Toxicology·J W HenckK J Olson
Jun 1, 1957·British Journal of Pharmacology and Chemotherapy·J L MONGAR

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Citations

Dec 1, 2009·Journal of Toxicologic Pathology·Klaus WeberMartin Rosenbruch

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