Inhalational Ciclesonide found beneficial in prevention of fat embolism syndrome and improvement of hypoxia in isolated skeletal trauma victims

European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society
R K SenI M Sen

Abstract

Many studies have established intravenous corticosteroid as an effective prophylactic therapy in fat embolism syndrome (FES). However, its use is limited among surgeons because of systemic side effects. Inhalational steroids have least systemic effects and are widely used for several chest conditions (i.e., asthma), but their effectiveness in FES has not been established. This study was sought to evaluate the (1) efficacy and (2) safety of inhalational Ciclesonide (CIC) in prevention of FES and treatment of hypoxemia in isolated skeletal trauma victims. A nonrandomized prospective control trial was designed in which all patients between 18 and 40 years with isolated skeletal injury who presented within 8 h of injury were allocated to either Trial group or control group. Trial group patients received 640 mcg of inhalational CIC with a metered-dose inhaler at the time of admission, and at 24 h. Control group patients did not receive any prophylactic therapy. Both groups were evaluated for development of FES (Gurd's criteria) and hypoxemia (PaO2<70 mmHg) for 72 h. The complications related to CIC administration were evaluated in trial group patients during their hospital stay. Of 35 patients in each group, two patients in Trial gr...Continue Reading

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Citations

Dec 20, 2017·Plastic and Reconstructive Surgery·Lázaro Cárdenas-CamarenaJorge Enrique Bayter-Marin
Jun 2, 2021·Anaesthesia Critical Care & Pain Medicine·Julien PottecherHervé Quintard

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