PMID: 8940720Aug 1, 1996Paper

Inhaled [13N]nitric oxide: a positron emission tomography (PET) study

Nuclear Medicine and Biology
T J McCarthyM J Welch

Abstract

Using positron emission tomography (PET) and nitric oxide radiolabeled with nitrogen-13 (half-life 9.97 min) we probed the distribution and kinetics of inhaled nitric oxide in anesthetized dogs. The washout of this gas after inhalation was much slower than that observed for [13N]nitrogen gas, demonstrating its uptake by lung tissue. The small fraction of radioactivity found in the plasma was determined to be in the form of [13N]nitrate. The administered gas contained < 1 ppm of nonradioactive nitric oxide, which is believed to be below the physiologic threshold for vasorelaxation.

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Citations

Mar 28, 2006·Proceedings of the American Thoracic Society·Timothy J McMahon, Allan Doctor
Apr 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·M P MoyaJ S Stamler
Jun 16, 2009·Free Radical Biology & Medicine·Hao HongWeibo Cai
Mar 6, 2004·Circulation Research·Jonathan S Stamler

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