Inhaled Antibiotic Therapy in Chronic Respiratory Diseases

International Journal of Molecular Sciences
Diego J MaselliMarcos I Restrepo

Abstract

The management of patients with chronic respiratory diseases affected by difficult to treat infections has become a challenge in clinical practice. Conditions such as cystic fibrosis (CF) and non-CF bronchiectasis require extensive treatment strategies to deal with multidrug resistant pathogens that includePseudomonas aeruginosa, Methicillin-resistantStaphylococcus aureus,Burkholderiaspecies and non-tuberculousMycobacteria(NTM). These challenges prompted scientists to deliver antimicrobial agents through the pulmonary system by using inhaled, aerosolized or nebulized antibiotics. Subsequent research advances focused on the development of antibiotic agents able to achieve high tissue concentrations capable of reducing the bacterial load of difficult-to-treat organisms in hosts with chronic respiratory conditions. In this review, we focus on the evidence regarding the use of antibiotic therapies administered through the respiratory system via inhalation, nebulization or aerosolization, specifically in patients with chronic respiratory diseases that include CF, non-CF bronchiectasis and NTM. However, further research is required to address the potential benefits, mechanisms of action and applications of inhaled antibiotics for the...Continue Reading

References

Oct 1, 1986·Radiology·P GrenierH Nahum
Jun 17, 1993·The New England Journal of Medicine·B W RamseyM A McBurnie
Aug 1, 1997·The European Respiratory Journal·C B WilsonR Wilson
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·A F BarkerJ Quan
Apr 24, 2001·Archives of Disease in Childhood·S CunninghamC Wallis
May 9, 2001·The Journal of Pediatrics·G M NixonK Grimwood
May 3, 2002·The New England Journal of Medicine·Alan F Barker
Oct 3, 2002·The European Respiratory Journal·M E HodsonJ R W Govan
Dec 14, 2002·American Journal of Respiratory and Critical Care Medicine·Ronald L GibsonUNKNOWN Cystic Fibrosis Therapeutics Development Network Study Group
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Tim W R LeeJames M Littlewood
Feb 12, 2005·Chest·Ghassan A AlothmanAllan L Coates
Feb 6, 2007·American Journal of Respiratory and Critical Care Medicine·David E GriffithUNKNOWN Infectious Disease Society of America
Mar 14, 2007·Pediatric Pulmonology·David E GellerCarol Conrad
May 1, 2007·Respiratory Medicine·Paul T KingPeter W Holmes
Nov 28, 2007·Pediatric Pulmonology·George Z Retsch-BogartUNKNOWN AZLI Phase II Study Group
Nov 30, 2007·The New England Journal of Medicine·Karen S McCoy
Feb 1, 2008·Thorax·A Smyth, J S Elborn
Jul 29, 2008·American Journal of Respiratory and Critical Care Medicine·Karen S McCoyA Bruce Montgomery
Apr 10, 2009·The European Respiratory Journal·M R LoebingerR Wilson
Sep 5, 2009·American Journal of Respiratory and Critical Care Medicine·Patrick A FlumeUNKNOWN Clinical Practice Guidelines for Pulmonary Therapies Committee
Feb 6, 2010·The Pediatric Infectious Disease Journal·Anne StoneLisa Saiman
Apr 14, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·John Denyer, Tony Dyche
Jul 16, 2010·Thorax·M C PasteurUNKNOWN British Thoracic Society Non-CF Bronchiectasis Guideline Group
Aug 21, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Bryan J WilliamsTimothy S Blackwell
Sep 28, 2010·American Journal of Respiratory and Critical Care Medicine·Maeve P MurrayAdam T Hill
Nov 16, 2010·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Michael W KonstanDavid E Geller
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·David E GellerUNKNOWN Mpex 204 Study Group
Jun 15, 2011·Trends in Microbiology·Elena B M BreidensteinRobert E W Hancock
Jul 26, 2011·The Journal of Antimicrobial Chemotherapy·Christopher M OermannA Bruce Montgomery

❮ Previous
Next ❯

Citations

May 29, 2018·Expert Review of Respiratory Medicine·Rodrigo AthanazioMiguel Ángel Martínez-García
Sep 20, 2018·Human Vaccines & Immunotherapeutics·Aymn Talat AbbasEsam Ibraheem Ahmed Azhar
Sep 15, 2018·American Journal of Respiratory and Critical Care Medicine·David E GriffithUNKNOWN CONVERT Study Group
Jan 19, 2019·Expert Opinion on Drug Delivery·Gregory Reychler, Jean-Bernard Michotte
Oct 26, 2018·The Journal of Antimicrobial Chemotherapy·Maizbha U AhmedJian Li
Dec 23, 2017·Expert Review of Clinical Pharmacology·Andrea S MelaniPaola Rottoli
Feb 6, 2019·Aerosol Science and Technology : the Journal of the American Association for Aerosol Research·Xin Heng, Donovan B Yeates
Jan 11, 2020·Frontiers in Bioengineering and Biotechnology·Cecilia VelinoMichele Iafisco
May 14, 2020·Journal of Personalized Medicine·Sean D McCarthyBrendan D Higgins
Jul 28, 2020·Journal of Clinical Medicine·Miguel Ángel Martínez-GarcíaFrancisco Casas
Oct 12, 2018·International Journal of Molecular Sciences·Francesco Blasi
Jan 9, 2021·Expert Opinion on Drug Delivery·Maria Gabriella MateraMario Cazzola
Jul 12, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hana DouaferJean Michel Brunel
Apr 6, 2021·International Journal of Nanomedicine·Alanood S AlmurshediAmany Z Mohamoud
Apr 27, 2021·Pharmaceutical Development and Technology·Sara BahrainianKambiz Gilani
Apr 20, 2021·Expert Review of Respiratory Medicine·Sujit Kumar DebnathAbdelwahab Omri
Jul 23, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·James D ChalmersJean-Louis Herrmann
Jul 7, 2021·Antimicrobial Agents and Chemotherapy·Maizbha U AhmedJian Li
Sep 11, 2021·Chemico-biological Interactions·Md Sadique HussainHari S Sharma
Sep 22, 2021·ACS Infectious Diseases·Mercedes Gonzalez-JuarreroBernd Meibohm
Jan 4, 2019·Respiration; International Review of Thoracic Diseases·Núria Bruguera-ÀvilaJorge Abad Capa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Advanced Drug Delivery Reviews
Patrick A Flume, Donald R VanDevanter
Respiratory Care
Marcos I RestrepoLuis F Reyes
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Mehdi MirsaeidiRuxana T Sadikot
© 2022 Meta ULC. All rights reserved