Inhaled budesonide in experimental chlorine gas lung injury: influence of time interval between injury and treatment

Intensive Care Medicine
J WangSten M Walther

Abstract

To examine the time window between injury and treatment during which nebulized corticosteroid lessens lung injury induced by chlorine gas inhalation. An experimental laboratory study. Academic research laboratory. Twenty-four juvenile female pigs. Twenty-four mechanically ventilated pigs were exposed to chlorine gas (400 PPM in air) for 20 min, then divided into four groups (six in each group). Nebulized budesonide (BUD) was given immediately (BUD 0 min), 30 min (BUD 30 min) or 60 min (BUD 60 min) after chlorine gas exposure. Six pigs receiving nebulized saline served as controls. Hemodynamics, gas exchange and lung mechanics were evaluated for 5 h after chlorine gas exposure. All animals had an immediate increase in airway and pulmonary artery pressure and a sharp drop of arterial oxygenation. The mean arterial oxygen tension of BUD 0 min and BUD 30 min animals was significantly higher than in the control and the BUD 60 min groups ( p<0.001). The recovery of lung compliance in the BUD 0 min and the BUD 30 min groups was significantly more rapid than in the control and the BUD 60 min groups ( p<0.001). The pulmonary wet to dry weight ratio was greater in the control group than in the BUD-treated groups ( p<0.05). Treatment with...Continue Reading

Citations

May 14, 2005·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Frank LoVecchioDonna Stevens
Apr 21, 2006·Critical Care Medicine·Jianpu WangSten M Walther
May 12, 2006·The Journal of Trauma·Andriy I BatchinskyLeopoldo C Cancio
Dec 18, 2009·Southern Medical Journal·Yunsur CevikSermet Sezigen
May 23, 2006·Emergency Medicine Journal : EMJ·D RussellP Rice
Aug 19, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Martin LeustikSadis Matalon
Jul 6, 2010·Proceedings of the American Thoracic Society·Carl W White, James G Martin
May 31, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·John E Vajner, Derrick Lung
Mar 5, 2011·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Dylan W de Lange, Jan Meulenbelt
Oct 8, 2014·Chest·Jeremy R BeitlerB Taylor Thompson
Oct 1, 2013·Journal of Critical Care·Emir FesticOgnjen Gajic
Mar 10, 2016·Toxicology and Applied Pharmacology·Gary W HoyleKenneth H Carson
Feb 18, 2005·Acta Anaesthesiologica Scandinavica·J WangS M Walther
Jun 27, 2013·Toxicology and Applied Pharmacology·Jing ChenGary W Hoyle
Jun 5, 2016·BMC Pulmonary Medicine·Ying-Nan JuGuo-Nian Wang
May 10, 2015·Experimental Biology and Medicine·Wei Gao, Nanying Ju
Jun 30, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Leopoldo C CancioTina Palmieri
Apr 19, 2017·Annals of the American Thoracic Society·Eleanor M SummerhillUNKNOWN ATS Terrorism and Inhalational Disasters Section of the Environmental, Occupational, and Population Health Assembly
May 24, 2015·Therapeutic Advances in Respiratory Disease·Carl A Ruthman, Emir Festic
Jun 21, 2018·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Elisabeth WigenstamSofia Jonasson
Sep 19, 2019·Toxicology Mechanisms and Methods·Satyanarayana Achanta, Sven-Eric Jordt
Sep 29, 2019·International Journal of Molecular Sciences·Daniela MokraJuraj Mokry
May 1, 2021·Toxicology Mechanisms and Methods·Rachel WatkinsBronwen Jugg
Jun 3, 2021·Medical Sciences : Open Access Journal·Faeq R Kukhon, Emir Festic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.