PMID: 9343270Oct 29, 1997Paper

Inhaled budesonide reduces lung hyperinflation in children with asthma

Acta Paediatrica
B E SekerelG Adalioğlu

Abstract

Previous studies have shown that asthmatics have hyperinflation as defined by larger total lung capacity. The present study was set up in order to document changes in asthma clinic, airway calibre, airway reactivity and lung volumes after budesonide treatment. After a 2-week run-in period, 28 children with moderate persistent asthma were treated in a double-blind manner either with budesonide (0.4 mg/day) or placebo for 8 weeks and, thereafter, all patients were treated with open-label budesonide for a further 20 weeks. Symptoms, bronchodilator requirements and airway calibre improved significantly after 8 weeks of treatment (p < 0.05 for each) and prolonged treatment did not cause any further improvement. Reduction in hyperreactivity was apparent only after 20-28 weeks of treatment. Total lung capacity decreased along with budesonide treatment in both groups suggesting that early introduction of an inhaled corticosteroid may be useful in the prevention of asthma-related remodelling of the lung and thoracic cage.

References

Oct 1, 1978·The American Review of Respiratory Disease·R BrownE R McFadden
May 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Mar 1, 1992·The Journal of the American Dental Association·J Pride
Dec 10, 1988·BMJ : British Medical Journal·S LozewiczR J Davies
Oct 1, 1993·The American Review of Respiratory Disease·P J Barnes, S Pedersen
Dec 1, 1993·The American Review of Respiratory Disease·P J MerkusP H Quanjer

Citations

May 10, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Joseph D SpahnErwin W Gelfand
Nov 1, 2001·The Cochrane Database of Systematic Reviews·N AdamsP W Jones

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Related Papers

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
O E AldreyN E Bianco
American Journal of Respiratory and Critical Care Medicine
S Pedersen
The Journal of Asthma : Official Journal of the Association for the Care of Asthma
R M KatzA S Rohr
© 2021 Meta ULC. All rights reserved