Abstract
Data regarding the role of inhaled colistin in critically ill pediatric patients without cystic fibrosis are scarce. Three children (one female), admitted to the intensive care unit (ICU) of a tertiary-care pediatric hospital in Athens, Greece, during 2004-2009 received inhaled colistin as monotherapy for tracheobronchitis (two children), and as adjunctive therapy for necrotizing pneumonia (one child). Colistin susceptible Acinetobacter baumannii and Pseudomonas aeruginosa were isolated from the cases' bronchial secretions specimens. All three children received inhaled colistin at a dosage of 75 mg diluted in 3 ml of normal saline twice daily (1,875,000 IU of colistin daily), for a duration of 25, 32, and 15 days, respectively. All three children recovered from the infections. Also, a gradual reduction, and finally total elimination of the microbial load in bronchial secretions was observed during inhaled colistin treatment in the reported cases. All three cases were discharged from the ICU. No bronchoconstriction or any other type of toxicity of colistin was observed. In conclusion, inhaled colistin was effective and safe for the treatment of two children with tracheobronchitis, and one child with necrotizing pneumonia. Furthe...Continue Reading
References
Sep 12, 1998·Annals of Internal Medicine·D J CookC Brun-Buisson
Feb 7, 2001·Chest·S L KatzA L Coates
Apr 24, 2001·Archives of Disease in Childhood·S CunninghamC Wallis
Jun 14, 2001·Journal of Clinical Pharmacology·M D ReedJ L Blumer
Oct 3, 2002·The European Respiratory Journal·M E HodsonJ R W Govan
Mar 9, 2004·European Journal of Clinical Pharmacology·Federico MarchettiBaroukh M Assael
Jan 22, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·David BerlanaR Jódar
Feb 8, 2005·Critical Care : the Official Journal of the Critical Care Forum·Argyris MichalopoulosMatthew E Falagas
Feb 12, 2005·Chest·Ghassan A AlothmanAllan L Coates
Dec 6, 2005·Journal of Chemotherapy·M HorianopoulouM E Falagas
Jan 7, 2006·The Journal of Antimicrobial Chemotherapy·F RatjenH Grasemann
Jul 1, 2006·Clinical Medicine & Research·Matthew E FalagasArgyris Michalopoulos
Feb 21, 2007·Expert Opinion on Pharmacotherapy·Jennifer K HagermanMichael E Klepser
Jun 1, 2007·Paediatric Drugs·Gerard LenoirNikolay Leonidovich Aryayev
Oct 9, 2007·Clinical Therapeutics·Craig LaForceAlison Webster
Dec 7, 2007·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Marie-Sophie BrochetJacques-Edouard Marcotte
Apr 29, 2008·Clinics in Chest Medicine·Rajiv Dhand, Vamsi P Guntur
Jun 17, 2008·Critical Care Medicine·Lucy B PalmerPaul Richman
Dec 5, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Paul Checchia
Jan 1, 2009·The Pediatric Infectious Disease Journal·Matthew E FalagasDimitris A Kafetzis
Jan 3, 2009·Respiratory Medicine·Matthew E FalagasArgyris Michalopoulos
Jan 27, 2009·International Journal of Antimicrobial Agents·Matthew E FalagasPetros I Rafailidis
Sep 1, 2009·American Journal of Surgery·Matthew E FalagasGeorge Peppas
Mar 6, 2010·Respiratory Medicine·Michalis AgrafiotisMatthew E Falagas
Citations
Jul 19, 2011·International Journal of Clinical Practice·G TheocharisM E Falagas
Apr 18, 2013·PloS One·Naoto YoshinoShigehiro Sato
Sep 14, 2013·Journal of Postgraduate Medicine·A K Dhariwal, M S Tullu
Feb 16, 2012·Expert Opinion on Drug Delivery·Sabina Antonela Antoniu, Ileana Cojocaru
Apr 16, 2011·International Journal of Antimicrobial Agents·Stephen P Hawser
May 6, 2015·Paediatric Drugs·Meltem PolatAnıl Dolgun
Dec 13, 2017·Antimicrobial Agents and Chemotherapy·Yu-Wei LinJian Li
Dec 18, 2013·Yonsei Medical Journal·Hee Kyoung ChoiYoung Uh
Aug 3, 2011·European Journal of Pediatrics·Istemi Han CelikUgur Dilmen
Jan 30, 2013·Pediatric Pulmonology·Chia-Hao KangHong-Ren Yu
Sep 8, 2020·Expert Opinion on Drug Safety·Kashif HussainJavaid Iqbal
May 27, 2016·Clinical Microbiology Reviews·Eric WenzlerLarry H Danziger