Inhaled colistin in elderly patients with non-cystic fibrosis bronchiectasis and chronic Pseudomonas aeruginosa bronchial infection

Revista española de geriatría y gerontología
Eva Tabernero HuguetJuan Luis Artola Igarza

Abstract

Bronchiectasis is a frequent cause of admission for elderly patients and chronic respiratory diseases. Although some guidelines recommend long-term treatment with inhaled antibiotics in non-cystic fibrosis bronchiectasis with chronic Pseudomonas aeruginosa (P. aeruginosa) infection, there is limited evidence supporting these prolonged antibiotic treatments in this population. The aim of this study was to assess the effectiveness of inhaled colistin in elderly patients with bronchiectasis and chronic bronchial P. aeruginosa infection in reducing hospital readmissions. A prospective, controlled and open label study was conducted on patients with bronchiectasis diagnosed by computed tomography and persistence of P. aeruginosa in sputum after appropriate antimicrobial therapy. All patients received education, and physiotherapy training. The intervention group also received nebulized colistin 1 million IU twice a day for one year. Data were collected on the demographics, clinical and functional characteristics, admissions in previous year, and sputum microbiology. Patients were followed up every two months for one year, with readmissions, microbiological results, functional tests, and deaths being evaluated. The study included 39 pa...Continue Reading

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Nov 23, 2015·The Cochrane Database of Systematic Reviews·Annemarie L LeeAnne E Holland
Jul 17, 2018·Expert Review of Respiratory Medicine·Rosanel AmaroAntoni Torres
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Jul 4, 2020·Therapeutic Advances in Respiratory Disease·Meng-Jiao Xu, Bing Dai
Dec 2, 2020·Journal of Clinical Medicine·Marta Garcia-ClementeMiguel Angel Martinez-García

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