Inhaled corticosteroids for asthma: are they all the same?

Journal of Clinical Pharmacy and Therapeutics
A P Baptist, R C Reddy

Abstract

To assess similarities and differences among currently available inhaled corticosteroids (ICS) for treatment of asthma, with special emphasis on factors that may affect the relative safety of these medications. PubMed was searched for relevant reviews and original articles. Information from these studies was synthesized and critically assessed. Differences in corticosteroid formulations and delivery systems can create variations in therapeutic efficacy. Chemical properties of the various corticosteroids may also affect their relative safety. Ciclesonide and beclomethasone dipropionate are administered as prodrugs activated by enzymes present in the lungs but not the oropharynx. Corticosteroid-specific adverse effects in the oropharynx are thus avoided, although formulation-specific effects may remain. Other adverse effects require systemic availability, either via the gastrointestinal tract or the lung. Once they enter the systemic circulation, all ICS are rapidly metabolized by the liver. Oral bioavailability of ICS such as fluticasone, ciclesonide and mometasone is minimal, as a result of their essentially complete first-pass metabolism in the liver. Ciclesonide also undergoes extrahepatic metabolism that eliminates it even m...Continue Reading

References

Jan 1, 1976·British Journal of Diseases of the Chest·R F WilleyI W Grant
Jul 6, 1991·Lancet·S TeelucksinghP R Holt
Jan 1, 1992·Chest·G G GuidryR B George
Mar 16, 1991·BMJ : British Medical Journal·E M PouwE Endert
Jun 16, 1990·BMJ : British Medical Journal·S CapewellA Y Finlay
Nov 1, 1995·The Journal of Allergy and Clinical Immunology·N A HananiaS Kesten
Dec 1, 1995·American Journal of Public Health·J F MarystoneD J Morton
Oct 1, 1994·The European Respiratory Journal·L ThorssonT B Conradson
Dec 1, 1994·British Journal of Clinical Pharmacology·A GrahnénA Ling-Andersson
Jan 1, 1994·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·J S LarsenK A Wick
Feb 1, 1993·The Journal of Allergy and Clinical Immunology·J H ToogoodC Dyson
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·P AutioA Oikarinen
Mar 5, 1997·JAMA : the Journal of the American Medical Association·E GarbeS Suissa
Feb 1, 1997·British Journal of Clinical Pharmacology·L ThorssonJ E Wirén
Jul 3, 1997·The New England Journal of Medicine·R G CummingS R Leeder
Aug 6, 1995·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·B Olsson
Jun 1, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·G R DickensS Choudhury
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·D JaffuelM Mathieu
Aug 15, 2000·Journal of Clinical Epidemiology·W A KennedyA P Contandriopoulos
Mar 1, 2002·The Cochrane Database of Systematic Reviews·A JonesG Roberts
Nov 29, 2002·Archives of Disease in Childhood·G R G ToddD McCance
Feb 27, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kerstin DahlströmKurt Nikander
May 2, 2003·Journal of Clinical Pharmacology·S RohatagiJ S Barrett
Sep 19, 2003·The Journal of Allergy and Clinical Immunology·H William Kelly, Harold S Nelson
Sep 26, 2003·The British Journal of Ophthalmology·L SmeethA E Fletcher
Jan 6, 2004·Fundamental & Clinical Pharmacology·Jean-Christophe DubusUNKNOWN Réseau de Recherche Clinique en Pneumologie Pédiatrique
Apr 7, 2004·Journal of Pharmaceutical Sciences·Anagnostis ValotisPetra Högger
May 14, 2004·Current Opinion in Pharmacology·Ian M Adcock, Kazuhiro Ito

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Citations

Sep 15, 2009·Journal of Veterinary Internal Medicine·N E RobinsonF J Derksen
Aug 27, 2011·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Alexandra AhmetSheldon Spier
Nov 6, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Arnulf LanghammerUnni Syversen
Jan 1, 2014·Journal of Pharmaceutical Policy and Practice·Faris El-DahiyatPenelope Bidgood
May 8, 2015·Lung India : Official Organ of Indian Chest Society·Ritesh AgarwalSubhash Varma
Sep 18, 2010·International Journal of Pediatric Otorhinolaryngology·Charles PudrithTimothy Jung
Mar 9, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M NassimiC Müller-Goymann
Dec 8, 2009·Pulmonary Pharmacology & Therapeutics·Gabriele NicoliniAndrea S Melani
Jan 27, 2011·The Journal of Small Animal Practice·N T Whitley, M J Day
Dec 24, 2010·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Clyde SchultzDouglas Morck
Feb 24, 2015·Journal of Voice : Official Journal of the Voice Foundation·Arzu TuzunerEtem Erdal Samim
Apr 8, 2015·Respiratory Research·Elisabeth A P M RommeEmiel F M Wouters
Apr 3, 2016·Clinical Endocrinology·L N Rao Bondugulapati, D A Rees
Jun 28, 2011·European Journal of Clinical Pharmacology·Maria A P MartinsAntonio L P Ribeiro
Dec 14, 2011·The Journal of Pharmacology and Experimental Therapeutics·Christopher A HewsonMichael Yeadon
Jul 28, 2019·Pulmonary Pharmacology & Therapeutics·Maria Gabriella MateraMario Cazzola
Jun 5, 2021·Journal of Veterinary Internal Medicine·Sophie Mainguy-Seers, Jean-Pierre Lavoie

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