Inhaled corticosteroids in asthma: which have the best tolerance?

Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie
N Forenza, S Ceccarelli

Abstract

Asthmatic syndrome, better definition of asthma, is an inflammatory chronic disease, probably the most frequent in pediatrics. An important characteristic of asthma is the bronchial inflammation with a complex network of cells and inflammatory mediators of pivotal importance in the pathogenesis. The long term control and treatment of this disease are cardinal points of the management of asthmatic syndrome. Inhaled corticosteroids (ICS) are the first-line treatment for persistent asthma in children of any age. The adverse events of the inhaled steroids on growth, bone mineralization, and hypothalamic-pituitary adrenal (HPA) axis function are the main concerns for the pediatricians. The long-term effects on growth and bone mineralization are actually reassuring. Good tolerance is achieved on hypothalamic-pituitary adrenal axis function with low to moderate doses in children. Scientific and clinical researches are pointed to find out molecules able to improve clinical efficacy of ICS with better tolerance and higher reduction of adverse events.

References

Jul 20, 1991·BMJ : British Medical Journal·O D Wolthers, S Pedersen
Oct 12, 2000·The New England Journal of Medicine·UNKNOWN Childhood Asthma Management Program Research GroupRobert Zeiger
Oct 12, 2000·The New England Journal of Medicine·L Agertoft, S Pedersen
Jun 29, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I TurktasP Cinaz
Sep 29, 2001·Allergy·J C DubusUNKNOWN Réseau de Recherche Clinique en Pneumonologie Pédiatrique
Feb 12, 2002·Pediatric Pulmonology·David B Allen
Apr 24, 2002·Pulmonary Pharmacology & Therapeutics·Shelby P UmlandSebastian L Johnston
Feb 27, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Tjeerd-Pieter van StaaCyrus Cooper
Feb 3, 2006·The European Respiratory Journal·P J Barnes
May 12, 2006·The New England Journal of Medicine·Theresa W GuilbertFernando D Martinez
Feb 10, 2007·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·V MarchacM Polak
Aug 8, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ekkehard Werner Zöllner
Dec 7, 2007·Allergy·L B BacharierUNKNOWN European Pediatric Asthma Group
Jan 2, 2008·The European Respiratory Journal·E D BatemanH J Zar
Aug 19, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Mathieu MolimardAntoine Tabarin
Sep 23, 2008·Lancet·Ian M AdcockK Fan Chung
Mar 27, 2009·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Lone Agertoft, Søren Pedersen
Apr 29, 2009·European Journal of Clinical Pharmacology·Amélie DaveluyMathieu Molimard
Apr 27, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jochen J RüdigerMichael Roth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.