Inhaled corticosteroids in chronic obstructive pulmonary disease: a review

Expert Opinion on Pharmacotherapy
Eef D TelengaMaarten van den Berge

Abstract

Chronic obstructive pulmonary disease (COPD) is a disease characterized by chronic airflow obstruction and a progressive lung function decline. Although widely used, the efficacy of inhaled corticosteroids (ICS) in the treatment of COPD remains a matter of debate. This article reviews the evidence about the effects of inhaled corticosteroids in the treatment of COPD. Short-term treatment with ICS improves lung function and quality of life; in addition, several studies with longer follow-up have shown less decline over time in quality of life, and fewer exacerbations. By contrast, long-term studies have been unable to show substantial improvement in the decline of lung function in COPD. Based on these findings, it was concluded that the use of ICS did not influence the natural course of COPD. However, this conclusion has been challenged by two subsequent studies, TORCH and GLUCOLD, which both showed a reduction in lung-function decline over time with the use of ICS. These two studies indicate that ICS might indeed influence the natural course of the disease, at least in a subgroup of COPD patients. Further studies are needed to identify which individuals have a favorable short- and long-term response to ICS treatment.

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Citations

Nov 3, 2011·The Journal of Endocrinology·Abraham B Roos, Magnus Nord
Jun 6, 2013·Expert Review of Respiratory Medicine·Sukhwinder Singh SohalEugene Haydn Walters
Oct 22, 2013·Expert Opinion on Pharmacotherapy·Mario CazzolaMaria Gabriella Matera
Dec 6, 2011·Ophthalmology·Jose Javier Garcia-MedinaManuel Garcia-Medina
Jan 8, 2016·Respiratory Research·I H HeijinkM van den Berge
Aug 8, 2014·British Journal of Clinical Pharmacology·K Suresh BabuJaymin B Morjaria
May 10, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bing ZhuDaniela Traini
Jan 23, 2015·American Journal of Respiratory and Critical Care Medicine·Stephanie A ChristensonPrescott G Woodruff
May 4, 2018·Thorax·Alessandro MarconUNKNOWN Ageing Lungs in European Cohorts (ALEC) study
Oct 16, 2014·North American Journal of Medical Sciences·Adrian Pedro Noriega Aldave, DO William Saliski
Jun 16, 2017·Epigenomics·Thea van den BoschFrank J Dekker
Sep 11, 2021·Chemico-biological Interactions·Md Sadique HussainHari S Sharma

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